Results 101 to 110 of about 6,054 (206)

Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development [PDF]

, 2000
Control of cellular proliferation in plant meristems is important for maintaining the correct number and position of developing organs. One of the genes identified in the control of floral and apical meristem size and floral organ number in Arabidopsis ...
Medrano, Leonard J., Meyerowitz, Elliot M., Ziegelhoffer, Eva C.   +2 more
core  

Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells

, 2001
Proteins belonging to the ras superfamily are involved in cell proliferation of normal and neoplastic tissues. To be biologically active, they require post-translational isoprenylation by farnesyl-transferase and geranylgeranyl-transferase.
LASTELLA M, BOGGI, UGO, MARCHETTI A, DEL TACCA M., MOSCA F, DANESI, ROMANO, DI PAOLO, ANTONELLO, CAPUTO S, MACCHIA, MARCO   +8 more
core   +1 more source

Genome Mining Reveals a UbiA-Type Prenyltransferase Access to Farnesylation of Diketopiperazines

UbiA-type prenyltransferases (PTases) are significant enzymes that lead to structurally diverse meroterpenoids. Herein, we report the identification and characterization of an undescribed UbiA-type PTase, FtaB, that is responsible for the farnesylation ...
Chuanteng Ma (10163706), Wenxue Wang (568075), Zian Wang (4952869), Dehai Li (1433623), Tianjiao Zhu (1433617), Qian Che (725671), Jiaqi Lin (1866724), Xiaotian Yu (6095210), Guojian Zhang (1604386), Jing Ge (443408)   +9 more
core   +1 more source

Targeting Lamin A Farnesylation: Implications for Osteogenesis and Therapeutic Strategies in Progeria Syndrome

Diese Masterarbeit untersucht die Rolle von Lamin A, einem wichtigen Protein für die Zellstruktur und Genregulation. Außerdem wird die Rolle von Lamin A im Zusammenhang mit verschiedenen Laminopathien, Krankheiten, die durch Mutationen in den Lamin-Genen
Hüller, Sandra Maria
core   +1 more source

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function. [PDF]

J Cell Sci
Lio C, Wang Y, Wilson PC, Li Y, Antoku S, Östlund C, Shin JY, Worman HJ, Chang W, Gundersen GG.   +9 more
europepmc   +1 more source

Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation. [PDF]

Int J Mol Sci
Yang S, Liu H, Kou H, Lai L, Zhang X, Xu Y, Sun Y, Chen B.   +7 more
europepmc   +1 more source

The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications. [PDF]

Biomolecules
Cao H, Liu X, Zhu S, Nie H, Liu S, Fan J, Qin W.   +6 more
europepmc   +1 more source

Protein lipidation in cardiovascular homeostasis, development, and disease. [PDF]

Clin Sci (Lond)
Cully D, Harrison S, Sadovsky M, Miner GE, Edwards W.   +4 more
europepmc   +1 more source

The Farnesyl Transferase Inhibitor Darlifarnib (KO-2806) Resensitizes Relapsing Tumors to RAS Inhibition. [PDF]

Cancer Res
Patel HV, Smith AE, Chan S, Gasendo JG, Jombik A, Greer JE, Samantaray T, Kessler L, Mitra A, Zhu X, Liu YA, Burrows F, Malik S.   +12 more
europepmc   +1 more source

Farnesylation Process [PDF]

, 2020
openaire   +1 more source