Results 91 to 100 of about 6,405 (188)

Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling

Biochemistry and Biophysics Reports
Neurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells.
Akiko Sotozono, Kazuhiko Namekata, Xiaoli Guo, Youichi Shinozaki, Chikako Harada, Takahiko Noro, Tadashi Nakano, Takayuki Harada   +7 more
doaj   +1 more source

The role of protein farnesylation in Arabidopsis seed development

, 2020
La farnésylation de protéine est une modification post-traductionnelle consistant en l’ajout d’un groupement farnésyl (C15) sur des protéines cibles équipées d’un motif appelé CaaX-box.
Vergés, Valentin
core  

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

, 2002
Farnesyl transferase inhibitors induce G2/M cell cycle delays that cannot be explained by inhibition of the Ras GTPase. Recently, the kinetochore protein Cenp-F has been shown to be farnesylated.
Taylor, Stephen S., Hussein, Deema
core   +2 more sources

Genome Mining Reveals a UbiA-Type Prenyltransferase Access to Farnesylation of Diketopiperazines

UbiA-type prenyltransferases (PTases) are significant enzymes that lead to structurally diverse meroterpenoids. Herein, we report the identification and characterization of an undescribed UbiA-type PTase, FtaB, that is responsible for the farnesylation ...
Chuanteng Ma (10163706), Wenxue Wang (568075), Zian Wang (4952869), Dehai Li (1433623), Tianjiao Zhu (1433617), Qian Che (725671), Jiaqi Lin (1866724), Xiaotian Yu (6095210), Guojian Zhang (1604386), Jing Ge (443408)   +9 more
core   +1 more source

Targeting Lamin A Farnesylation: Implications for Osteogenesis and Therapeutic Strategies in Progeria Syndrome

Diese Masterarbeit untersucht die Rolle von Lamin A, einem wichtigen Protein für die Zellstruktur und Genregulation. Außerdem wird die Rolle von Lamin A im Zusammenhang mit verschiedenen Laminopathien, Krankheiten, die durch Mutationen in den Lamin-Genen
Hüller, Sandra Maria
core   +2 more sources

Sortase A-Mediated Farnesylation of Cdc42 <i>In Vitro</i>. [PDF]

ACS Synth Biol
Tschirpke S, Hettema NM, Spitzbarth B, de Geus MAR, van Opstal F, Eelkema R, Laan L.   +6 more
europepmc   +1 more source

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function. [PDF]

J Cell Sci
Lio C, Wang Y, Wilson PC, Li Y, Antoku S, Östlund C, Shin JY, Worman HJ, Chang W, Gundersen GG.   +9 more
europepmc   +1 more source

Plasmodium-induced disruption of brain endothelial barrier integrity in vitro and in mice is prevented by inhibitors of farnesyltransferase. [PDF]

Malar J
Gomes C, Crotty KA, Borges Silva MC, Vasquez M, Chicas L, Salzano I, Rodriguez A.   +6 more
europepmc   +1 more source

Mevalonate pathway rewiring driven by enhancer remodelling confers resistance to KRAS inhibitors in colorectal cancer. [PDF]

Nat Commun
Guo Y, Zhong Y, Hu P, Chen Y, Guo W, Chen J, Guan P, Zhou Z, Zhu F, Zeng X, Gao J, Xiong Q, Yu Z, Hu C, Cai Z, Xie X, Hong JH, Chan JY, Wang W, Diao D, Xia X, Yu Q, Ong CK, Gao Y, Wu X, Tan J.   +25 more
europepmc   +1 more source

Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation. [PDF]

Int J Mol Sci
Yang S, Liu H, Kou H, Lai L, Zhang X, Xu Y, Sun Y, Chen B.   +7 more
europepmc   +1 more source