Results 91 to 100 of about 6,054 (206)

N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A

, 2013
Hutchinson-Gilford progeria syndrome is caused by mutations in the lamin A/C gene that lead to expression of a truncated, permanently farnesylated prelamin A variant called progerin.
Anna M. Malfitano, Maria G. Caruso, D'Alessandro A, Notarnicola M, Chiara Laezza, Maria Notarnicola, Malfitano AM, Maurizio Bifulco, Bifulco M, MALFITANO, ANNA MARIA, Laezza C., Caruso MG, PALADINO, SIMONA, Alba D'Alessandro, Simona Paladino, BIFULCO, Maurizio   +15 more
core   +1 more source

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Nature Communications, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death.
Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson   +17 more
doaj   +1 more source

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

, 2005
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is characterized by dramatic premature aging and accelerated cardiovascular disease.
Erdos, M. R., Fiordalisi, J. J., Madigan, J. P., Varga, R., Cox, A. D., Gordon, L. B., Collins, F. S., Capell, B. C., Conneely, K. N., Der, C. J.   +9 more
core   +1 more source

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

, 2002
Farnesyl transferase inhibitors induce G2/M cell cycle delays that cannot be explained by inhibition of the Ras GTPase. Recently, the kinetochore protein Cenp-F has been shown to be farnesylated.
Taylor, Stephen S., Hussein, Deema
core   +3 more sources

The role of protein farnesylation in Arabidopsis seed development

, 2020
La farnésylation de protéine est une modification post-traductionnelle consistant en l’ajout d’un groupement farnésyl (C15) sur des protéines cibles équipées d’un motif appelé CaaX-box.
Vergés, Valentin
core  

Synthesis and farnesylation of a-factor fusion proteins in Saccharomyces cerevisiae

, 1993
We have generated in-frame fusions between the mouse dihydrofolate reductase (DHFR) and parts of the a-factor MFA1 gene to explore the potential of a-factor as a secretion signal for larger polypeptides.
Ralf Kölling, Benjamin Böttner, Kölling, Ralf, Hollenberg, Cornelis P., Böttner, Benjamin, Cornelis P. Hollenberg   +5 more
core   +1 more source

Farnesylation of Ydj1 Is Required for In Vivo Interaction with Hsp90 Client Proteins

, 2008
Ydj1 of Saccharomyces cerevisiae is an abundant cytosolic Hsp40, or J-type, molecular chaperone. Ydj1 cooperates with Hsp70 of the Ssa family in the translocation of preproteins to the ER and mitochondria and in the maturation of Hsp90 client proteins ...
Lemieszek, Marta, Johnson, Jill L, Flom, Gary A, Fortunato, Elizabeth A   +3 more
core   +1 more source

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo

, 2006
Background: Available in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via farnesylation or geranylgeranylation (for example, autoradiography with 3H-labeled anchor precursors) are time consuming (weeks ...
Benetka, Wolfgang (Universität Wien), Maurer-Stroh, Sebastian (Universität Wien), Koranda, Manfred (University of Vienna), Eisenhaber, Frank (University of Vienna), Pittner, Fritz (University of Vienna)   +4 more
core   +1 more source

Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling

Biochemistry and Biophysics Reports
Neurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells.
Akiko Sotozono, Kazuhiko Namekata, Xiaoli Guo, Youichi Shinozaki, Chikako Harada, Takahiko Noro, Tadashi Nakano, Takayuki Harada   +7 more
doaj   +1 more source

Reduced farnesylation of cpx enhances AZ localization and alters interactions with SNARE proteins.

, 2018
(A) Maximal projection confocal images of w1118 NMJs in Ctrl, following 60 min of exposure to NO or farnesylation inhibitor (“farnesyl inh”: 10 μM GGTI-298 + 20 μM L-744,832).
Julie-Myrtille Bourgognon (5076140), Adrian Butcher (5076146), Flaviano Giorgini (58325), Tim M. Smith (5076134), R. A. John Challiss (187685), Susan W. Robinson (2453929), Jereme G. Spiers (5076131), Giovanna R. Mallucci (500637), Carlo Breda (5076125), Maria Guerra-Martin (5076143), Raj Mistry (5076128), Nobuhiro Morone (214081), Joern R. Steinert (331102), David Dinsdale (282533), Susanna Campesan (5076137)   +14 more
core   +1 more source