Results 91 to 100 of about 9,367 (212)

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane

Scientific Reports, 2017
Within macrophages and amoeba, the Legionella-containing vacuole (LCV) membrane is derived from the ER. The bona fide F-box AnkB effector protein of L.
John D. Perpich, Awdhesh Kalia, Christopher T. D. Price, Snake C. Jones, Kathy Wong, Kalle Gehring, Yousef Abu Kwaik   +6 more
doaj   +1 more source

Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Lamins are intermediate filament proteins that constitute the main components of the lamina underlying the inner-nuclear membrane and serve to organize chromatin.
Khadija G. Syeda, Anjan Kowluru
doaj   +1 more source

Reversible inactivation of the transcriptional function of P53 protein by farnesylation

BMC Biotechnology, 2006
Background The use of integrating viral vectors in Gene therapy clinical trials has pointed out the problem of the deleterous effect of the integration of the ectopic gene to the cellular genome and the safety of this strategy.
Berg Danièle, Casteignau Antoine, Pradines Anne, Tohfe Mustapha, Penary Marie, Couderc Bettina, Favre Gilles   +6 more
doaj   +1 more source

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT, Bednar MM, Bellosta S, Buttrum SM, Buyon JP, Calara F, Calderon TM, Diacovo TG, Giroux LM, Jukema JW, Kim JA, Kimura M, Laufs U, Laws KH, Lehr H-A, Marcus AJ, Notabartolo A, Olstrowsky L, Pons F, Ruf A, Smalley DM, Stragliotto E, Sugiyama S, Weber C, Weber C, Weber C, Yeagle PL, Yeo EL, Yue TL   +28 more
core   +1 more source

Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis

mSphere, 2016
Prenyltransferase enzymes promote the membrane localization of their target proteins by directing the attachment of a hydrophobic lipid group at a conserved C-terminal CAAX motif.
Shannon K. Esher, Kyla S. Ost, Lukasz Kozubowski, Dong-Hoon Yang, Min Su Kim, Yong-Sun Bahn, J. Andrew Alspaugh, Connie B. Nichols   +7 more
doaj   +1 more source

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) [PDF]

, 2012
BACKGROUND: Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins.
A Boni, A Hauschild, AD Basso, AL Shada, April KS Salama, AS Yazdi, C Robert, CJ Punt, Cynthia Bucher, D Dankort, Donna Niedzwiecki, DS Hong, DW End, E Atallah, FE Meier, FE Meier, Frank Haluska, FS Hodi, Gerald Linette, H Tsao, H Tsao, J Ackermann, J Czyzyk, JA Sosman, JA Sparano, JE Karp, JE Lancet, Jeffrey Johnson, JL Harousseau, JY Han, K Satyamoorthy, K Zhu, KA Margolin, KL van Golen, KS Smalley, KT Flaherty, M Alsina, M Crul, M Huncharek, MB Atkins, Michelle A Blaskovich, MR Middleton, MS Brose, N Berndt, N Dhomen, P Guldberg, PB Chapman, R Kefford, R Kurzrock, R Kurzrock, RA Mesa, RA Padua, RE Marks, SA Rosenberg, SA Rosenberg, Said M Sebti, T Hocker, Thomas F Gajewski, TM Zimmerman, V’t Veer LJ, Z Ji   +60 more
core   +2 more sources

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aberrant
Rajakrishnan Veluthakal, Daleep K. Arora, Marc L. Goalstone, Renu A. Kowluru, Anjaneyulu Kowluru   +4 more
doaj   +1 more source

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus

Frontiers in Microbiology, 2018
RasA is a major regulator of fungal morphogenesis and virulence in Aspergillus fumigatus. The proper localization of RasA to the plasma membrane is essential for the formation of invasive hyphae during infection.
Qusai Al Abdallah, Adela Martin-Vicente, Ana Camila Oliveira Souza, Wenbo Ge, Jarrod R. Fortwendel   +4 more
doaj   +1 more source