Results 71 to 80 of about 6,405 (188)

Understanding the Role of Farnesylation During the Cross-talk Between Brassinosteroids and Abscisic Acid Responses

, 2016
Protein farnesylation is a post-translational modification involving the addition of a 15-carbon farnesyl isoprenoid to the carboxy terminus of select proteins.
Liang, Siyu Jr
core   +1 more source

Updates on protein-prenylation and associated inherited retinopathies

Frontiers in Ophthalmology
Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao   +3 more
doaj   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

, 2016
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a dramatic appearance of premature aging. HGPS is due to a single-base substitution in exon 11 of the LMNA gene (c.1824C>T) leading to the production of a toxic form ...
Le Corf, A., Laustriat, D., Georges, P, Jaskowiak, A-L, Blondel S, Notarnicola, M, Peschanski M, Bauvais, C, Georges P, Jaskowiak, Anne-Laure, Tournois, J, Bollot, G., Tournois, J., Bifulco, M., Le Corf, A, Peschanski, M., Laustriat D, Georges, P., Nissan, X., Pitrez P R, Laustriat, D, Bifulco Maurizio, De Sandre-Giovannoli A, Jaskowiak A-L, Notarnicola M, Ragot, J, Navarro, C, Bollot G, De Sandre Giovannoli, A, Mejat, A, Ragot, J., NOTARNICOLA, MARIA, Jaskowiak, A. L, Lévy, Nicolas, Tournois J, Ferreira, L., Levy N, Blondel, S, BIFULCO, Maurizio, Laustriat, Delphine, Pitrez, P. R., Bollot, G, Brinon, B, PICARDI, PAOLA, Egesipe, Anne-Laure, Pitrez, P. R, Egesipe A-L, Poydenot, P., Le Corf, Amélie, Ferreira, L, Picardi P, Brinon B, Picardi, P., Levy, N, Navarro C, Egesipe, A-L, Mejat A, Mejat, A., Poydenot, P, Le Corf A, Ragot J, Poydenot, Pauline, Bauvais, C., Ferreira L, Nissan X, Brinon, B., de Sandre-Giovannoli, Annachiara, Navarro, C., Poydenot P, Peschanski, M, Brinon, Benjamin, Navarro, Claire, L., De Sandre-Giovannoli, A., Egesipe, A. L, Levy, N., Notarnicola, M., Bauvais C, Blondel, S.   +77 more
core   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Farnesylation mediates brassinosteroid biosynthesis to regulate abscisic acid responses

, 2016
Protein farnesylation is a post-translational modification involving the addition of a 15-carbon farnesyl isoprenoid to the carboxy terminus of select proteins1–3.
Liang, S (15642131), McCourt, P (15574718), Deb, S (15645602), Jamshed, M (15645599), James Reid (14747746), Eloise Foo (14736721), Northey, JGB (15645596), Samuel, MA (15645605)   +7 more
core  

Exploitation of host polyubiquitination machinery through molecular mimicry by eukaryotic-like bacterial F-box effectors

Frontiers in Cellular and Infection Microbiology, 2010
Microbial pathogens have evolved exquisite mechanisms to interfere and intercept host biological processes, often through molecular mimicry of specific host proteins.
Yousef eAbu Kwaik, Christopher T. Price
doaj   +1 more source

Farnesylation-dependent regulation of transcripts by PARP13

, 2015
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.Cataloged from PDF version of thesis.Includes bibliographical references.PARP1 3 is a RNA-binding and catalytically inactive member of the poly(ADPribose) (PARP) family ...
Uchima, Lilen
core  

Host-mediated post-translational prenylation of novel Dot/Icm-translocated effectors of Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2010
The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price, Snake C Jones, Karen E Amundson, Yousef eAbu Kwaik   +3 more
doaj   +1 more source

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19

, 2017
The transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor. Recognition of cargo PMPs by the C-terminal domain (CTD) of PEX19 is required for peroxisome biogenesis in vivo. Farnesylation at a
Juliane Radke, Michael Sattler, Ulrike Schütz, Robert Rucktäschel, Wolfgang Schliebs, Tobias Madl, Ralf Erdmann, Konstantinos Tripsianes, Leonidas Emmanouilidis, Matthias Wilmanns   +9 more
core   +2 more sources