Results 71 to 80 of about 9,367 (212)

Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells

Journal of Lipid Research, 2003
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (42) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans.
Rosa A. Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M. Baccino   +8 more
doaj   +1 more source

Reversible Binding and Trafficking of DNA Origami Between Lipid Membrane Phases

Small Structures, Volume 7, Issue 1, January 2026.
A DNA origami nanostructure was functionalized with different lipophilic anchor types. Depending on the anchor type, these nanodevices selectively bind to a certain lipid phase with distinctive rigidities. Using the strand displacement method, these functionalized DNA origami nanostructures go through dimerization/monomerization steps, thereby ...
Rayehe Mamaghaniyeh, Henri G. Franquelim
wiley   +1 more source

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Journal of Lipid Research, 2005
Prelamin A undergoes multistep processing to yield lamin A, a structural protein of the nuclear lamina. Prelamin A terminates with a CAAX motif, which triggers farnesylation of a C-terminal cysteine (the C of the CAAX motif), endoproteolytic release of ...
Stephen G. Young, Loren G. Fong, Susan Michaelis   +2 more
doaj   +1 more source

USP45 and Spindly are part of the same complex implicated in cell migration [PDF]

, 2018
Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Conte, Claudia, Griffis, Eric, Hickson, Ian D., Perez-Oliva, Ana   +3 more
core   +2 more sources

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, Volume 59, Issue 1, January 2026.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

The role of lipid post-translational modification in plant developmental processes

Frontiers in Plant Science, 2014
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key modification is the attachment of a lipid group to certain amino acids; this typically facilitates subcellular targeting ...
Mark Paul Running
doaj   +1 more source

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans. [PDF]

PLoS ONE, 2016
Genetic pathways that regulate nascent neurite formation play a critical role in neuronal morphogenesis. The core planar cell polarity components VANG-1/Van Gogh and PRKL-1/Prickle are involved in blocking inappropriate neurite formation in a subset of ...
David Carr, Leticia Sanchez-Alvarez, Janice H Imai, Cristina Slatculescu, Nathaniel Noblett, Lei Mao, Lorena Beese, Antonio Colavita   +7 more
doaj   +1 more source

Epithelial stem cells In Hutchinson-Gilford progeria syndrome [PDF]

, 2015
Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which ...
McKenna, Tomás
core   +1 more source

Competition between binding partners of yeast Pex3 affects peroxisome biology

The FEBS Journal, Volume 293, Issue 1, Page 175-195, January 2026.
Pex3 is a peroxisomal membrane protein (PMP) that specifically recruits several binding partners. In the yeast Hansenula polymorpha, Atg30 (pexophagy), Inp1 (inheritance) and Pex19 (receptor for new PMPs) associate with Pex3. Overexpression of any of these proteins affects peroxisomal processes because these proteins compete for binding to Pex3.
Eline M. F. de Lange, Grzegorz Chojnowski, Jérôme Bürgi, Rifka Vlijm, Matthias Wilmanns, Ida J van der Klei   +5 more
wiley   +1 more source

Updates on protein-prenylation and associated inherited retinopathies

Frontiers in Ophthalmology
Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao   +3 more
doaj   +1 more source