Results 61 to 70 of about 6,054 (206)

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation

, 2011
To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates Rac1 in the induction of angiogenesis, we studied the role of 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase and αPix.
Nikhlesh K. Singh, Venkatesh Kundumani-Sridharan, Gadiparthi N. Rao   +2 more
core   +1 more source

Tools To Analyze Protein Farnesylation in Cells

, 2016
Farnesylation of proteins is catalyzed by protein farnesyl transferase (FTase) and is obligatory for the function of the oncoprotein Ras and a variety of other physiologically important proteins.
H. Peter Spielmann (527546), Douglas A. Andres (317978), Michael J. Roberts (337238), Jerry M. Troutman (1333854)   +3 more
core   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

, 2017
The transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor. Recognition of cargo PMPs by the C-terminal domain (CTD) of PEX19 is required for peroxisome biogenesis in vivo. Farnesylation at a
Radke, J., Rucktaeschel, R., Wilmanns, M., Erdmann, R., Schütz, U., Tripsianes, K., Emmanouilidis, L., Sattler, M., Madl, T., Schliebs, W.   +9 more
core   +2 more sources

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Journal of Lipid Research, 2005
Prelamin A undergoes multistep processing to yield lamin A, a structural protein of the nuclear lamina. Prelamin A terminates with a CAAX motif, which triggers farnesylation of a C-terminal cysteine (the C of the CAAX motif), endoproteolytic release of ...
Stephen G. Young, Loren G. Fong, Susan Michaelis   +2 more
doaj   +1 more source

The role of lipid post-translational modification in plant developmental processes

Frontiers in Plant Science, 2014
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key modification is the attachment of a lipid group to certain amino acids; this typically facilitates subcellular targeting ...
Mark Paul Running
doaj   +1 more source

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans. [PDF]

PLoS ONE, 2016
Genetic pathways that regulate nascent neurite formation play a critical role in neuronal morphogenesis. The core planar cell polarity components VANG-1/Van Gogh and PRKL-1/Prickle are involved in blocking inappropriate neurite formation in a subset of ...
David Carr, Leticia Sanchez-Alvarez, Janice H Imai, Cristina Slatculescu, Nathaniel Noblett, Lei Mao, Lorena Beese, Antonio Colavita   +7 more
doaj   +1 more source

pH‐Responsive Isoprenoid‐Antitumoral Polymer Conjugates for Superior Drug Loading via Self‐Assembly and Endosomal‐Targeted Anticancer Activity

ChemMedChem, Volume 21, Issue 2, January 2026.
Polymer‐drug conjugate (PDC) entirely composed of active compounds with pH‐responsive properties. The PDC can self‐assemble into nanoparticles for intracellular delivery and endosome‐targeted efficacy. Polymer‐drug conjugates (PDCs) are a promising strategy to enhance the delivery of poorly soluble drugs, particularly in cancer therapy.
Camilla Passi, Tobias Neu, Nicole Schneider‐Daum, Claus‐Michael Lehr, Marc Schneider, Sangeun Lee   +5 more
wiley   +1 more source

Farnesylation-mediated control of skotomorphogenesis and seedling establishment in Arabidopsis thaliana

Skotomorphogenesis is growth in the dark, a critical process in the establishment of seedlings for all crop systems in which the seed is sown below the soil surface.
Hickerson, Neil Murray
core   +1 more source

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

, 2016
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a dramatic appearance of premature aging. HGPS is due to a single-base substitution in exon 11 of the LMNA gene (c.1824C>T) leading to the production of a toxic form ...
Le Corf, A., Laustriat, D., Georges, P, Jaskowiak, A-L, Blondel S, Notarnicola, M, Peschanski M, Bauvais, C, Georges P, Jaskowiak, Anne-Laure, Tournois, J, Bollot, G., Tournois, J., Bifulco, M., Le Corf, A, Peschanski, M., Laustriat D, Georges, P., Nissan, X., Pitrez P R, Laustriat, D, Bifulco Maurizio, De Sandre-Giovannoli A, Jaskowiak A-L, Notarnicola M, Ragot, J, Navarro, C, Bollot G, De Sandre Giovannoli, A, Mejat, A, Ragot, J., NOTARNICOLA, MARIA, Jaskowiak, A. L, Lévy, Nicolas, Tournois J, Ferreira, L., Levy N, Blondel, S, BIFULCO, Maurizio, Laustriat, Delphine, Pitrez, P. R., Bollot, G, Brinon, B, PICARDI, PAOLA, Egesipe, Anne-Laure, Pitrez, P. R, Egesipe A-L, Poydenot, P., Le Corf, Amélie, Ferreira, L, Picardi P, Brinon B, Picardi, P., Levy, N, Navarro C, Egesipe, A-L, Mejat A, Mejat, A., Poydenot, P, Le Corf A, Ragot J, Poydenot, Pauline, Bauvais, C., Ferreira L, Nissan X, Brinon, B., de Sandre-Giovannoli, Annachiara, Navarro, C., Poydenot P, Peschanski, M, Brinon, Benjamin, Navarro, Claire, L., De Sandre-Giovannoli, A., Egesipe, A. L, Levy, N., Notarnicola, M., Bauvais C, Blondel, S.   +77 more
core   +1 more source