Results 61 to 70 of about 6,405 (188)

Farnesylation of Pex19p is required for its structural integrity and function in Peroxisome Biogenesis

, 2009
The conserved CaaX box peroxin Pex19p is known to be modified by farnesylation. The possible involvement of this lipid modification in peroxisome biogenesis, the degree to which Pex19p is farnesylated, and its molecular function are unknown or ...
Pechlivanis, Markos, Halbach, Andre, Thoms, Sven, Sidorovitch, Vadim, Alexandrov, Kirill, Rottensteiner, Hanspeter, Erdmann, Ralf, Volkmer, Rudolf, Rucktaschel, Robert, Kuhlmann, Jürgen   +9 more
core   +1 more source

Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells

Journal of Lipid Research, 2003
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (42) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans.
Rosa A. Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M. Baccino   +8 more
doaj   +1 more source

Tools To Analyze Protein Farnesylation in Cells

, 2016
Farnesylation of proteins is catalyzed by protein farnesyl transferase (FTase) and is obligatory for the function of the oncoprotein Ras and a variety of other physiologically important proteins.
H. Peter Spielmann (527546), Douglas A. Andres (317978), Michael J. Roberts (337238), Jerry M. Troutman (1333854)   +3 more
core   +1 more source

Preventing Farnesylation of the Dynein Adaptor Spindly Contributes to the Mitotic Defects Caused by Farnesyltransferase Inhibitors [PDF]

, 2015
The clinical interest in farnesyltransferase inhibitors (FTIs) makes it important to understand how these compounds affect cellular processes involving farnesylated proteins.
Gassmann, Reto, Holland, Andrew J, Spielmann, H Peter, Niessen, Sherry, Reis, Rita M, Pereira, Cláudia, Andres, Douglas A., Andres, Douglas A, Holland, Andrew J., Cleveland, Don W., Reis, Rita M., Cleveland, Don W, Spielmann, H. Peter, Desai, Arshad   +13 more
core   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Journal of Lipid Research, 2005
Prelamin A undergoes multistep processing to yield lamin A, a structural protein of the nuclear lamina. Prelamin A terminates with a CAAX motif, which triggers farnesylation of a C-terminal cysteine (the C of the CAAX motif), endoproteolytic release of ...
Stephen G. Young, Loren G. Fong, Susan Michaelis   +2 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The role of lipid post-translational modification in plant developmental processes

Frontiers in Plant Science, 2014
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key modification is the attachment of a lipid group to certain amino acids; this typically facilitates subcellular targeting ...
Mark Paul Running
doaj   +1 more source

Targeted Therapies for Each Subtype of Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu, Puchao Peng, Yeke Zhu, Qiuwen Fei, Weiwei Liu, Shizhen Zhang   +5 more
wiley   +1 more source

Farnesylation-mediated control of skotomorphogenesis and seedling establishment in Arabidopsis thaliana

Skotomorphogenesis is growth in the dark, a critical process in the establishment of seedlings for all crop systems in which the seed is sown below the soil surface.
Hickerson, Neil Murray
core   +1 more source