Results 41 to 50 of about 6,405 (188)

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Heat-shock protein 40 is the key farnesylation target in meristem size control, abscisic acid signaling, and drought resistance [PDF]

, 2017
Protein farnesylation is central to molecular cell biology. In plants, protein farnesyl transferase mutants are pleiotropic and exhibit defective meristem organization, hypersensitivity to the hormone abscisic acid, and increased drought resistance.
Esther Botterweg Paredes, Peter Brodersen, Brodersen, Peter, Maïna Floris, Sjögren, Lars Ludvig Erland, Lars Sjögren, Stephan Wenkel, Wenkel, Stephan, Barghetti, Andrea, Floris, Maina Huguette Joséphine, Andrea Barghetti, Botterweg Paredes, Esther   +11 more
core   +1 more source

Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. [PDF]

PLoS Genetics, 2013
The core planar polarity proteins are required to specify the orientation of structures that are polarised in the plane of the epithelium. In the Drosophila melanogaster wing, the core proteins localise asymmetrically at either proximal or distal cell ...
Helen Strutt, Vickie Thomas-MacArthur, David Strutt   +2 more
doaj   +1 more source

Focus on DnaJ protein research from Arabidopsis to crop improvement

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract DnaJ proteins (Hsp40s) are essential components of the cellular proteostasis network, functioning as molecular co‐chaperones that regulate protein folding, stability, and stress‐responsive homeostasis in plants. Beyond their classical role as Hsp70 partners, accumulating evidence demonstrates that DnaJ proteins participate in diverse ...
Muhammad Arif, Hafiz Mamoon Rehman, Sehrish Bashir, Noman Mahmood, Atul Kumar Srivastava, Yakov Kuzyakov, Moh Sajid Ansari, Hon‐Ming Lam, Mingfang Yang   +8 more
wiley   +1 more source

The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.
UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan   +3 more
wiley   +1 more source

The effect of farnesylation at the C-terminus of super ecliptic pHluorin A227D on the response properties of ArcLight.

, 2014
A) Top: Schematic topology of ArcLight-S249 with a farnesylation site. Bottom: Sequence of ArcLight-S249 with a farnesylation site. The farnesylation site added to the C-terminus of the fluorescent protein is shaded with pink.
Zhou Han (490317), Lawrence B. Cohen (490318), Joseph J. Loturco (5661562), Fuyi Chen (561870), Lei Jin (120473), Josef Lazar (665063), Vincent A. Pieribone (136659), Alexey Bondar (665062)   +7 more
core   +1 more source

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency

Cellular Physiology and Biochemistry, 2017
Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico, Alessandra Romeo, Rossella Gratton, Sergio Crovella, Fulvio Celsi   +4 more
doaj   +1 more source

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

Redox Biology, 2020
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics ...
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai   +9 more
doaj   +1 more source

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

eLife, 2019
Delivery of native or chemically modified recombinant proteins into mammalian cells shows promise for functional investigations and various technological applications, but concerns that sub-cellular localization and functional integrity of delivered ...
Amal Alex, Valentina Piano, Soumitra Polley, Marchel Stuiver, Stephanie Voss, Giuseppe Ciossani, Katharina Overlack, Beate Voss, Sabine Wohlgemuth, Arsen Petrovic, Yaowen Wu, Philipp Selenko, Andrea Musacchio, Stefano Maffini   +13 more
doaj   +1 more source

Prelamin A Farnesylation and Progeroid Syndromes [PDF]

Journal of Biological Chemistry, 2006
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a LMNA mutation that leads to the synthesis of a mutant prelamin A that is farnesylated but cannot be further processed to mature lamin A. A more severe progeroid disorder, restrictive dermopathy (RD), is caused by the loss of the prelamin A-processing enzyme, ZMPSTE24.
Stephen G, Young, Margarita, Meta, Shao H, Yang, Loren G, Fong   +3 more
openaire   +2 more sources