Results 41 to 50 of about 6,054 (206)
Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity [PDF]
, 2011 The facial branchiomotor neurons (FBMNs) undergo a characteristic tangential migration in the vertebrate hindbrain. We previously used a morpholino knockdown approach to reveal that zebrafish prickle1b (pk1b) is required for this migration.
Cecilia B. Moens +4 more
core +1 more source
Prelamin A Farnesylation and Progeroid Syndromes [PDF]
Journal of Biological Chemistry, 2006 Hutchinson-Gilford progeria syndrome (HGPS) is caused by a LMNA mutation that leads to the synthesis of a mutant prelamin A that is farnesylated but cannot be further processed to mature lamin A. A more severe progeroid disorder, restrictive dermopathy (RD), is caused by the loss of the prelamin A-processing enzyme, ZMPSTE24.
Stephen G, Young +3 more
openaire +2 more sources
Farnesylation of Retinal Transducin Underlies Its Translocation during Light Adaptation
, 2005 SummaryG proteins are posttranslationally modified by isoprenylation: either farnesylation or geranylgeranylation. The γ subunit of retinal transducin (Tα/Tβγ) is selectively farnesylated, and the farnesylation is required for light signaling mediated by
Xiong, Wei-Hong +12 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2000 Pancreatic ductal adenocarcinoma is a highly lethal malignancy that is resistant to traditional cytotoxic therapy. High rates of activating codon 12 K-Ras mutations in this disease have generated considerable interest in the therapeutic application of ...
Si Young Song +4 more
doaj +1 more source
Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
doaj +1 more source
, 2023 Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. Reduced PGC-1α abundance is linked to skeletal muscle weakness in aging or pathological conditions, such as neurodegenerative diseases
Lee, Yun-Il +25 more
core +1 more source
Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. [PDF]
PLoS Genetics, 2013 The core planar polarity proteins are required to specify the orientation of structures that are polarised in the plane of the epithelium. In the Drosophila melanogaster wing, the core proteins localise asymmetrically at either proximal or distal cell ...
Helen Strutt +2 more
doaj +1 more source
Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides
Cells, 2018 The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino ...
Xiang Lu, Karima Djabali
doaj +1 more source
Heat-shock protein 40 is the key farnesylation target in meristem size control, abscisic acid signaling, and drought resistance [PDF]
, 2017 Protein farnesylation is central to molecular cell biology. In plants, protein farnesyl transferase mutants are pleiotropic and exhibit defective meristem organization, hypersensitivity to the hormone abscisic acid, and increased drought resistance.
Esther Botterweg Paredes +11 more
core +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source