Results 21 to 30 of about 6,054 (206)

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis [PDF]

FEBS Open Bio
Acute myeloid leukemia (AML) is a bone marrow malignancy characterized by arrested early‐stage hematopoietic precursor development. Differentiation therapy, which induces terminal differentiation of immature leukemic cells, is less toxic than standard ...
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
doaj   +2 more sources

PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease

, 2021
Accumulation of the parkin-interacting substrate (PARIS; ZNF746), due to inactivation of parkin, contributes to Parkinson's disease (PD) through repression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC- 1α; PPARGC1A) activity. Here,
Neifert, S, Khang, R, Chou, SC, Jo, A, Ham, S, Oh, S, Tessarollo, L, Dawson, TM, Jiang, H, Shin, JH, Lee, Y, Dawson, VL, Andrabi, SA, Cho, JW, Mao, X, Lee, YI, Na, CH, Kang, SU, Paek, SH, Kam, TI, Pirooznia, S, Ko, HS, Swing, DA, Kim, H, Kang, H, Umanah, GKE, Lee, BD, Karuppagounder, SS, Kang, HC, Park, CH, Kumar, M, Lee, JY, Park, H   +32 more
core   +1 more source

Coordination of Rheb lysosomal membrane interactions with mTORC1 activation [version 1; peer review: 4 approved]

F1000Research, 2020
A complex molecular machinery converges on the surface of lysosomes to ensure that the growth-promoting signaling mediated by mechanistic target of rapamycin complex 1 (mTORC1) is tightly controlled by the availability of nutrients and growth factors ...
Brittany Angarola, Shawn M. Ferguson
doaj   +1 more source

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors [PDF]

Journal of Cell Science, 2006
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive ...
Rusiñol, Antonio, Sinensky, Michael S.   +1 more
openaire   +4 more sources

Lamin A, farnesylation and aging [PDF]

Experimental Cell Research, 2012
Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LMNA gene, which result in the ...
Sita, Reddy, Lucio, Comai
openaire   +2 more sources

Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies

Nucleus, 2020
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj   +1 more source

An essential farnesylated kinesin in Trypanosoma brucei. [PDF]

PLoS ONE, 2011
Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson, Frederick S Buckner, Wesley C Van Voorhis   +2 more
doaj   +1 more source

Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system [PDF]

Disease Models & Mechanisms
Emily R. Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H. Kim, Walter K. Schmidt   +4 more
doaj   +2 more sources

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

Journal of Lipid Research, 2020
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina.
Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong   +14 more
doaj   +1 more source

A plant protein farnesylation system in prokaryotic cells reveals Arabidopsis AtJ3 produced and farnesylated in E. coli maintains its function of protecting proteins from heat inactivation

Plant Methods, 2023
Background Protein farnesylation involves the addition of a 15-carbon polyunsaturated farnesyl group to proteins whose C-terminus ends with a CaaX motif.
Jia-Rong Wu, Rida Zohra, Ngoc Kieu Thi Duong, Ching-Hui Yeh, Chung-An Lu, Shaw-Jye Wu   +5 more
doaj   +1 more source