Results 21 to 30 of about 6,405 (188)

Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover. [PDF]

Aging Cell
Hutchinson-Gilford Progeria syndrome (HGPS) is a severe premature ageing disorder caused by a 50 amino acid truncated (Δ50AA) and permanently farnesylated lamin A (LA) mutant called progerin.
Foo MXR, Ong PF, Yap ZX, Maric M, Bong CJS, Dröge P, Burke B, Dreesen O.   +7 more
europepmc   +2 more sources

PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease

, 2021
Accumulation of the parkin-interacting substrate (PARIS; ZNF746), due to inactivation of parkin, contributes to Parkinson's disease (PD) through repression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC- 1α; PPARGC1A) activity. Here,
Neifert, S, Khang, R, Chou, SC, Jo, A, Ham, S, Oh, S, Tessarollo, L, Dawson, TM, Jiang, H, Shin, JH, Lee, Y, Dawson, VL, Andrabi, SA, Cho, JW, Mao, X, Lee, YI, Na, CH, Kang, SU, Paek, SH, Kam, TI, Pirooznia, S, Ko, HS, Swing, DA, Kim, H, Kang, H, Umanah, GKE, Lee, BD, Karuppagounder, SS, Kang, HC, Park, CH, Kumar, M, Lee, JY, Park, H   +32 more
core   +1 more source

Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies

Nucleus, 2020
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj   +1 more source

A plant protein farnesylation system in prokaryotic cells reveals Arabidopsis AtJ3 produced and farnesylated in E. coli maintains its function of protecting proteins from heat inactivation

Plant Methods, 2023
Background Protein farnesylation involves the addition of a 15-carbon polyunsaturated farnesyl group to proteins whose C-terminus ends with a CaaX motif.
Jia-Rong Wu, Rida Zohra, Ngoc Kieu Thi Duong, Ching-Hui Yeh, Chung-An Lu, Shaw-Jye Wu   +5 more
doaj   +1 more source

Farnesylation of Retinal Transducin Underlies Its Translocation during Light Adaptation [PDF]

, 2005
SummaryG proteins are posttranslationally modified by isoprenylation: either farnesylation or geranylgeranylation. The γ subunit of retinal transducin (Tα/Tβγ) is selectively farnesylated, and the farnesylation is required for light signaling mediated by
Xiong, Wei-Hong, Satomi, Yoshinori, Yau, King-Wai, Imai, Hiroo, Takao, Toshifumi, Shichida, Yoshinori, Katsuki, Motoya, Fukada, Yoshitaka, Aiba, Atsu, Nakamura, Kenji, Nakao, Kazuki, Kassai, Hidetoshi, Okano, Toshiyuki   +12 more
core   +1 more source

Lamin A, farnesylation and aging [PDF]

Experimental Cell Research, 2012
Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LMNA gene, which result in the ...
Sita, Reddy, Lucio, Comai
openaire   +2 more sources

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

Journal of Lipid Research, 2010
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a farnesyltransferase inhibitor (FTI) ameliorates the disease ...
Shao H. Yang, Sandy Y. Chang, Douglas A. Andres, H. Peter Spielmann, Stephen G. Young, Loren G. Fong   +5 more
doaj   +1 more source

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Acta Neuropathologica Communications, 2021
The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD.
Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö, Ling Li   +5 more
doaj   +1 more source

Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias

Cells, 2022
Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular ...
Rhiannon M. Sears, Kyle J. Roux
doaj   +1 more source