Results 1 to 10 of about 6,054 (206)

Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation

Scientific Reports, 2017
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia.
Harumasa Nakazawa, Kazuhiro Ikeda, Shohei Shinozaki, Masayuki Kobayashi, Yuichi Ikegami, Ming Fu, Tomoyuki Nakamura, Shingo Yasuhara, Yong-Ming Yu, J. A. Jeevendra Martyn, Ronald G. Tompkins, Kentaro Shimokado, Tomoko Yorozu, Hideki Ito, Satoshi Inoue, Masao Kaneki   +15 more
doaj   +2 more sources

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Molecular characterization of exploitation of the polyubiquitination and farnesylation machineries of Dictyostelium discoideum by the AnkB F-box effector of Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2011
The Dot/Icm-translocated Ankyrin B (AnkB) F-box effector of L. pneumophila is essential for intra-vacuolar proliferation and functions as a platform for the docking of polyubiquitinated proteins to the Legionella-containing vacuole (LCV) within ...
Yousef eAbu Kwaik, Tasneem eAl-Quadan
doaj   +1 more source

Farnesyl Diphosphate Synthase Assay

, 2014
Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15). This short-chain prenyl diphosphate constitutes a key branch-point of the isoprenoid biosynthetic pathway ...
Arró, Montserrat, Manzano, David, Ferrer, Albert   +2 more
openaire   +3 more sources

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Targeted Therapies for Each Subtype of Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu, Puchao Peng, Yeke Zhu, Qiuwen Fei, Weiwei Liu, Shizhen Zhang   +5 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells

Journal of Lipid Research, 2003
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (42) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans.
Rosa A. Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M. Baccino   +8 more
doaj   +1 more source