Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle [PDF]
PLoS ONE, 2015 OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients.
Harumasa Nakazawa +2 more
exaly +10 more sources
Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis [PDF]
FEBS Open BioAcute myeloid leukemia (AML) is a bone marrow malignancy characterized by arrested early‐stage hematopoietic precursor development. Differentiation therapy, which induces terminal differentiation of immature leukemic cells, is less toxic than standard ...
Mina Noura +7 more
doaj +3 more sources
PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms [PDF]
Journal of VirologyPeroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chaoqun Chen +8 more
doaj +2 more sources
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer [PDF]
iScienceSummary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. Farnesyltransferase inhibitors (FTIs), such as tipifarnib, are being tested in cancer therapy.
Yanbo Pan +9 more
doaj +2 more sources
PLoS Computational Biology, 2011 Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate ...
Nir London +2 more
exaly +3 more sources
A plant protein farnesylation system in prokaryotic cells reveals Arabidopsis AtJ3 produced and farnesylated in E. coli maintains its function of protecting proteins from heat inactivation [PDF]
Plant Methods, 2023 Background Protein farnesylation involves the addition of a 15-carbon polyunsaturated farnesyl group to proteins whose C-terminus ends with a CaaX motif.
Jia-Rong Wu +5 more
doaj +2 more sources
Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico +4 more
doaj +3 more sources
Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling [PDF]
Biochemistry and Biophysics ReportsNeurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells.
Akiko Sotozono +7 more
doaj +2 more sources
An essential farnesylated kinesin in Trypanosoma brucei. [PDF]
PLoS ONE, 2011 Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson +2 more
doaj +1 more source
Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system [PDF]
Disease Models & MechanismsEmily R. Hildebrandt +4 more
doaj +2 more sources