Results 1 to 10 of about 6,405 (188)
PLoS Computational Biology, 2011 Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate ...
Carol A Fierke +2 more
exaly +4 more sources
Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle [PDF]
PLoS ONE, 2015 OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients.
Ronald Tompkins, Harumasa Nakazawa
exaly +4 more sources
Protein Farnesylation Takes Part in Arabidopsis Seed Development
Frontiers in Plant Science, 2021 Protein farnesylation is a post-translational modification regulated by the ERA1 (Enhanced Response to ABA 1) gene encoding the β-subunit of the protein farnesyltransferase in Arabidopsis.
Christelle Dutilleul +2 more
exaly +4 more sources
MSphere, 2018 Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or ...
Tomokazu Yoshizaki, J S Pagano
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Frontiers in Molecular Neuroscience, 2018 Primary cilia are microtubule-based organelles, which protrude from the plasma membrane and receive a wide range of extracellular signals. Various cilia use G protein-coupled receptors (GPCRs) for the detection of these signals.
Maxim Sokolov +2 more
exaly +3 more sources
Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin [PDF]
PLoS ONE, 2011 BACKGROUND: Ras protein, as one of intracellular signal switches, plays various roles in several cell activities such as differentiation and proliferation.
Yi Liang, Jun-Ming Liao
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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors [PDF]
Journal of Cell Science, 2006 Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive ...
Rusiñol, Antonio +1 more
openaire +4 more sources
F1000Research, 2020 A complex molecular machinery converges on the surface of lysosomes to ensure that the growth-promoting signaling mediated by mechanistic target of rapamycin complex 1 (mTORC1) is tightly controlled by the availability of nutrients and growth factors ...
Brittany Angarola, Shawn M. Ferguson
doaj +1 more source
An essential farnesylated kinesin in Trypanosoma brucei. [PDF]
PLoS ONE, 2011 Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson +2 more
doaj +1 more source
Journal of Lipid Research, 2020 Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina.
Patrick J. Heizer +14 more
doaj +1 more source