Results 31 to 40 of about 6,405 (188)
Angewandte Chemie, Volume 138, Issue 27, 1 July 2026.This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong +2 more
wiley +2 more sources
Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity [PDF]
, 2011 The facial branchiomotor neurons (FBMNs) undergo a characteristic tangential migration in the vertebrate hindbrain. We previously used a morpholino knockdown approach to reveal that zebrafish prickle1b (pk1b) is required for this migration.
Cecilia B. Moens +4 more
core +1 more source
Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
Natasha Emmanuel +9 more
doaj +1 more source
Journal of Lipid Research, 2010 Over a hundred proteins in eukaryotic cells carry a C-terminal CaaX box sequence, which targets them for posttranslational isoprenylation of the cysteine residue.
Julia M. Fres +2 more
doaj +1 more source
Protein farnesylation in plants--conserved mechanisms but different targets.
, 2003 Protein farnesylation has an important role in the regulation of plant development and signal transduction, but the exact function of this modification is not well understood.
Galichet A, Gruissem W
core +1 more source
Lamin A-linked progerias: is farnesylation the be all and end all? [PDF]
, 2010 The Publisher's final version can be found by following the DOI link.HGPS (Hutchinson-Gilford progeria syndrome) is a severe childhood disorder that appears to mimic an accelerated aging process. The disease is most commonly caused by gene mutations that
Sue Shackleton +3 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2000 Pancreatic ductal adenocarcinoma is a highly lethal malignancy that is resistant to traditional cytotoxic therapy. High rates of activating codon 12 K-Ras mutations in this disease have generated considerable interest in the therapeutic application of ...
Si Young Song +4 more
doaj +1 more source
Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +1 more source
Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides
Cells, 2018 The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino ...
Xiang Lu, Karima Djabali
doaj +1 more source