Results 51 to 60 of about 6,054 (206)

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

The effect of farnesylation at the C-terminus of super ecliptic pHluorin A227D on the response properties of ArcLight.

, 2014
A) Top: Schematic topology of ArcLight-S249 with a farnesylation site. Bottom: Sequence of ArcLight-S249 with a farnesylation site. The farnesylation site added to the C-terminus of the fluorescent protein is shaded with pink.
Zhou Han (490317), Lawrence B. Cohen (490318), Joseph J. Loturco (5661562), Fuyi Chen (561870), Lei Jin (120473), Josef Lazar (665063), Vincent A. Pieribone (136659), Alexey Bondar (665062)   +7 more
core   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency

Cellular Physiology and Biochemistry, 2017
Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico, Alessandra Romeo, Rossella Gratton, Sergio Crovella, Fulvio Celsi   +4 more
doaj   +1 more source

Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin. [PDF]

PLoS ONE, 2011
BACKGROUND: Ras protein, as one of intracellular signal switches, plays various roles in several cell activities such as differentiation and proliferation.
Ling-Jia Wu, Li-Rong Xu, Jun-Ming Liao, Jie Chen, Yi Liang   +4 more
doaj   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

eLife, 2019
Delivery of native or chemically modified recombinant proteins into mammalian cells shows promise for functional investigations and various technological applications, but concerns that sub-cellular localization and functional integrity of delivered ...
Amal Alex, Valentina Piano, Soumitra Polley, Marchel Stuiver, Stephanie Voss, Giuseppe Ciossani, Katharina Overlack, Beate Voss, Sabine Wohlgemuth, Arsen Petrovic, Yaowen Wu, Philipp Selenko, Andrea Musacchio, Stefano Maffini   +13 more
doaj   +1 more source

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

Redox Biology, 2020
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics ...
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai   +9 more
doaj   +1 more source

Farnesylation of Pex19p is required for its structural integrity and function in Peroxisome Biogenesis

, 2009
The conserved CaaX box peroxin Pex19p is known to be modified by farnesylation. The possible involvement of this lipid modification in peroxisome biogenesis, the degree to which Pex19p is farnesylated, and its molecular function are unknown or ...
Pechlivanis, Markos, Halbach, Andre, Thoms, Sven, Sidorovitch, Vadim, Alexandrov, Kirill, Rottensteiner, Hanspeter, Erdmann, Ralf, Volkmer, Rudolf, Rucktaschel, Robert, Kuhlmann, Jürgen   +9 more
core   +1 more source

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila

, 2010
Farnesylation involves covalent linkage of eukaryotic proteins to a lipid moiety to anchor them into membranes, which is essential for the biological function of Ras and other proteins.
Snake C. Jones, Yousef Abu Kwaik, Christopher T.D. Price, Tasneem Al-Quadan, Abu Kwaik, Yousef, Price, Christopher T.D., Marina Santic, Šantić, Marina, Jones, Snake C., Al-Quadan, Tasneem   +9 more
core   +1 more source