Results 51 to 60 of about 9,367 (212)

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

Farnesyl Diphosphate Synthase Assay

, 2014
Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15). This short-chain prenyl diphosphate constitutes a key branch-point of the isoprenoid biosynthetic pathway ...
Arró, Montserrat, Manzano, David, Ferrer, Albert   +2 more
openaire   +3 more sources

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

Redox Biology, 2020
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics ...
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai   +9 more
doaj   +1 more source

Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin. [PDF]

PLoS ONE, 2011
BACKGROUND: Ras protein, as one of intracellular signal switches, plays various roles in several cell activities such as differentiation and proliferation.
Ling-Jia Wu, Li-Rong Xu, Jun-Ming Liao, Jie Chen, Yi Liang   +4 more
doaj   +1 more source

Mouse models for understanding the molecular mechanism of bone disease in Hutchinson-Gilford progeria syndrome [PDF]

, 2011
Aging is a complex process affecting all people. Intense research is applied to elucidate the biological basis of aging and disease that develop with aging.
Schmidt, Eva
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

eLife, 2019
Delivery of native or chemically modified recombinant proteins into mammalian cells shows promise for functional investigations and various technological applications, but concerns that sub-cellular localization and functional integrity of delivered ...
Amal Alex, Valentina Piano, Soumitra Polley, Marchel Stuiver, Stephanie Voss, Giuseppe Ciossani, Katharina Overlack, Beate Voss, Sabine Wohlgemuth, Arsen Petrovic, Yaowen Wu, Philipp Selenko, Andrea Musacchio, Stefano Maffini   +13 more
doaj   +1 more source

Targeted Therapies for Each Subtype of Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu, Puchao Peng, Yeke Zhu, Qiuwen Fei, Weiwei Liu, Shizhen Zhang   +5 more
wiley   +1 more source

Molecular characterization of exploitation of the polyubiquitination and farnesylation machineries of Dictyostelium discoideum by the AnkB F-box effector of Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2011
The Dot/Icm-translocated Ankyrin B (AnkB) F-box effector of L. pneumophila is essential for intra-vacuolar proliferation and functions as a platform for the docking of polyubiquitinated proteins to the Legionella-containing vacuole (LCV) within ...
Yousef eAbu Kwaik, Tasneem eAl-Quadan
doaj   +1 more source