Results 11 to 20 of about 6,054 (206)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis [PDF]

Advanced Science
Cardiomyocyte senescence contributes to cardiac fibrosis, yet the molecular mechanisms remain unclear. Farnesylation is a post‐translational modification critical for cholesterol metabolism and is mediated by the farnesyltransferase beta subunit (FNTB ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
doaj   +3 more sources

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity

PLoS Computational Biology, 2011
Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate ...
Nir London, James L Hougland, Carol A Fierke   +2 more
exaly   +4 more sources

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle [PDF]

PLoS ONE, 2015
OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients.
Harumasa Nakazawa, Tomokazu Tanaka, Joshua Kramer   +2 more
exaly   +4 more sources

PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms [PDF]

Journal of Virology
Peroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chaoqun Chen, Guanning Su, Yuchen Wang, Yuanxiang Xiong, Wenwen Xiao, Zhuang Li, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +8 more
doaj   +2 more sources

Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARγ Expression and Activation in Differentiating Mesenchymal Stem Cells [PDF]

PPAR Research, 2007
Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into ...
Daniel Rivas, Rahima Akter, Gustavo Duque   +2 more
doaj   +2 more sources

Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer [PDF]

iScience
Summary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. Farnesyltransferase inhibitors (FTIs), such as tipifarnib, are being tested in cancer therapy.
Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre   +9 more
doaj   +2 more sources

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2-Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging. [PDF]

Aging Cell
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Zhang S, Qi J, Liu C, Zhang H, Guo B, Wu D, Liu Y, Zhen X, Zhang Y, Kang N, Zhou J, Yan G, Li C, Ding L, Sun H.   +14 more
europepmc   +2 more sources

Protein Farnesylation Takes Part in Arabidopsis Seed Development

Frontiers in Plant Science, 2021
Protein farnesylation is a post-translational modification regulated by the ERA1 (Enhanced Response to ABA 1) gene encoding the β-subunit of the protein farnesyltransferase in Arabidopsis.
Valentin Vergès, Christelle Dutilleul, Béatrice Godin, Boris Collet, Alain Lecureuil, Loïc Rajjou, Cyrille Guimaraes, Michelle Pinault, Stéphane Chevalier, Nathalie Giglioli-Guivarc’h, Eric Ducos   +10 more
doaj   +2 more sources

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.

PLoS Biology, 2018
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation.
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert   +14 more
doaj   +3 more sources

C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes

mSphere, 2018
Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or ...
E. Kobayashi, M. Aga, S. Kondo, C. Whitehurst, T. Yoshizaki, J. S. Pagano, J. Shackelford   +6 more
doaj   +2 more sources