Results 11 to 20 of about 6,405 (188)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis [PDF]

Advanced Science
Cardiomyocyte senescence contributes to cardiac fibrosis, yet the molecular mechanisms remain unclear. Farnesylation is a post‐translational modification critical for cholesterol metabolism and is mediated by the farnesyltransferase beta subunit (FNTB ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
doaj   +3 more sources

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability. [PDF]

PLoS Biology, 2018
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation.
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert   +14 more
doaj   +10 more sources

Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARγ Expression and Activation in Differentiating Mesenchymal Stem Cells [PDF]

PPAR Research, 2007
Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into ...
Daniel Rivas, Rahima Akter, Gustavo Duque   +2 more
doaj   +2 more sources

PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms [PDF]

Journal of Virology
Peroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome ...
Chaoqun Chen, Guanning Su, Yuchen Wang, Yuanxiang Xiong, Wenwen Xiao, Zhuang Li, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +8 more
doaj   +2 more sources

Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond [PDF]

Frontiers in Pharmacology
Protein farnesylation, catalyzed by farnesyltransferase (FTase), covalently attaches a 15-carbon farnesyl lipid to cysteine residues within C-terminal CaaX motifs.
Jiacheng Lou, Danlu Zhang, Yingjie Wang, Yingjie Wang   +3 more
doaj   +2 more sources

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis [PDF]

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +2 more sources

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2‐Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging [PDF]

Aging Cell, Volume 25, Issue 2, February 2026.
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang, Jiahui Qi, Chuanming Liu, Huidan Zhang, Bichun Guo, Die Wu, Yicen Liu, Xin Zhen, Yang Zhang, Nannan Kang, Jidong Zhou, Guijun Yan, Chaojun Li, Lijun Ding, Haixiang Sun   +14 more
wiley   +2 more sources

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies [PDF]

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +2 more sources

Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer [PDF]

iScience
Summary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. Farnesyltransferase inhibitors (FTIs), such as tipifarnib, are being tested in cancer therapy.
Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre   +9 more
doaj   +2 more sources

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis [PDF]

FEBS Open Bio
Acute myeloid leukemia (AML) is a bone marrow malignancy characterized by arrested early‐stage hematopoietic precursor development. Differentiation therapy, which induces terminal differentiation of immature leukemic cells, is less toxic than standard ...
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
doaj   +2 more sources