Results 11 to 20 of about 9,367 (212)
Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2-Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging. [PDF]
Aging CellA schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Zhang S +14 more
europepmc +2 more sources
F1000Research, 2020 A complex molecular machinery converges on the surface of lysosomes to ensure that the growth-promoting signaling mediated by mechanistic target of rapamycin complex 1 (mTORC1) is tightly controlled by the availability of nutrients and growth factors ...
Brittany Angarola, Shawn M. Ferguson
doaj +1 more source
Development of a Genetically Encoded and Potent PDE6D Inhibitor. [PDF]
ChembiochemPDE6D is a trafficking chaperone of prenylated proteins. Current small molecule PDE6D inhibitors target its hydrophobic pocket, rendering them typically poorly water soluble. Herein, PDE6D binders are generated by combining parts of the K‐Ras4B and INPP5E C‐termini. The genetically encoded high‐affinity PDE6D inhibitor SNAP‐STI is thus generated.
Gómez-Mulas A +7 more
europepmc +2 more sources
Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum [PDF]
, 2014 Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase?
Cirulli, Brenda Analía +5 more
core +8 more sources
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj +1 more source
Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors [PDF]
Journal of Cell Science, 2006 Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive ...
Rusiñol, Antonio +1 more
openaire +4 more sources
Journal of Lipid Research, 2020 Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina.
Patrick J. Heizer +14 more
doaj +1 more source
Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]
, 2016 Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P +7 more
core +2 more sources
PPAR Research, 2007 Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into ...
Daniel Rivas +2 more
doaj +1 more source
Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]
, 2015 BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir +7 more
core +2 more sources