Results 211 to 220 of about 53,667,156 (250)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Age-related changes in adiposity and cardiometabolic disease risk: a longitudinal and prospective study in the UK Biobank. [PDF]

Int J Obes (Lond)
Rask-Andersen M, Lo Faro V, Karlsson T, Johansson Å.   +3 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Anticholinergic Burden in Elderly People in Nursing Homes: Cross-Sectional Assessment Using ACB Calculator and CRIDECO Anticholinergic Load Scale. [PDF]

Medicines (Basel)
Nascimento T, Matos MA, Pinto E.
europepmc   +1 more source

Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility. [PDF]

Gut
Díaz-Muñoz C, Bozzarelli I, Lopera-Maya EA, Belbasis L, Lo Faro V, Camargo Tavares L, Heredia-Fernández F, Di Lorenzo B, Sinha T, Esteban Blanco C, Favé MJ, Awadalla P, Walters RG, Bonfiglio F, Zhernakova A, Sanna S, D'Amato M.   +16 more
europepmc   +1 more source

Epidemiology and treatment of respiratory nematode infections in western European hedgehogs (<i>Erinaceus europaeus</i>). [PDF]

Int J Parasitol Parasites Wildl
Jota Baptista C, Gama I, Serena J, Heneberg P, Cásero M, Madeira de Carvalho L.   +5 more
europepmc   +1 more source

Current capacity of Portuguese specialized dementia centers in the era of anti-amyloid antibodies. [PDF]

Alzheimers Dement (Amst)
Tábuas-Pereira M, Silva-Spínola A, Agostinho C, Alves L, Araújo R, Bernardes C, Branco M, Borbinha C, Cabreira V, Costa S, Silva AD, Durães J, Faustino P, Félix C, Fernandes A, Ferreira J, Gago M, Guarda C, Ionel C, Jesus-Ribeiro J, Laranjinha I, Leitão A, Letra L, Lopes das Neves P, Maia LF, Machado Á, Martins B, Massano J, Mendonça A, Mendonça M, Miguel R, Miranda M, Morgado J, Nóbrega C, Coutinho MP, Oliveira T, Pita F, Sabença F, Rocha S, Ruano L, Santos T, Simões do Couto F, Taipa R, Cruz VT, Valverde AH, Vélon A, Verdelho A, Viana Baptista M, Vieira D, Lima M, Oliveira TG, Santana I, Scientific Alliance of Units Dedicated to Alzheimer's Disease (SAUDAD) consortium.   +52 more
europepmc   +1 more source

Diagnostic Predictive Scores of Amyloid Cardiomyopathy in Patients with Heart Failure with Preserved Ejection Fraction and Left Ventricular Hypertrophy. [PDF]

J Cardiovasc Dev Dis
Faro DC, Romeo F, Losi V, Simonetti D, Capodanno D, Monte IP.   +5 more
europepmc   +1 more source

Gut Microbiome Variation Across Menstrual Phases: Distinct Roles of Diet and Physiological Hormonal Fluctuations in Healthy Women

Sanna S, Faro VL, Forabosco P, Crobu F, Carta A, Busonero F, Maschio A, Viscito M, Lenarduzzi S, Vriz GB, Badalini A, Ferrando M, Chillotti F, Incollu S, Murrau D, De Seta F, Ricci G, Barbara G, Guerriero S, Meloni A, Barbaro M, Girotto G, Zhernakova D, Camarda S.   +23 more
europepmc   +1 more source