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Molekularer Mechanismus der Fas Ligand-induzierten Aktivierung der sauren Sphingomyelinase

, 2013
Mario Stephan
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Fas, Fas ligand,and transfusion immunomodulation

Transfusion, 2001
dem-onstrated that soluble HLA class I (sHLA-I) moleculesupregulate FasL expression and sFasL secretion in activatedFas-positive CD8+ T-cells and trigger their apoptosis. Thelevel of sHLA-I molecules is significantly increased in theserum of patients with an activation of their immune sys-tem, such as occurs during acute rejection of organ al-lografts,
PUPPO, FRANCESCO, GHIO M., CONTINI, PAOLA, MAZZEI C., INDIVERI, FRANCESCO   +4 more
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Fas/Fas ligand and hematopoietic progenitor cells

Current Opinion in Hematology, 1998
Fas antigen is a receptor that crosslinks with a ligand or antibody initiating a signal transduction cascade that leads to apoptosis. During normal hematopoiesis, Fas antigen is not expressed on CD34+ cells, including premature hematopoietic progenitor cells. Functioning Fas antigen expression is induced by several hematopoietic regulators.
Y, Niho, Y, Asano
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Structure and Function of Fas/Fas Ligand

International Reviews of Immunology, 1999
Fas is a member of the TNF receptor family, that contain 2-6 cysteine-rich domains (CRDs) in their extracellular regions, a single transmembrane domain and variably sized intracytoplasmic domains. Fas belongs to a subgroup of family members that have a "death domain" near the carboxy-terminal region of the molecule.
J R, Orlinick, A K, Vaishnaw, K B, Elkon
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Fas ligand: receptor or ligand?

Apoptosis, 1999
In this review, we chronicle the discovery, biochemical characterization, and assignment of Fas (CD95) as receptor and Fas Ligand (FasL, CD95L) as ligand. We review the functional descriptions of the molecules as death-inducing receptor and ligand or as mediators of cell division and/or growth arrest.
M K, Newell, J, Desbarats
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Fas Ligand-Induced Apoptosis

Annual Review of Genetics, 1999
▪ Abstract  The immune response is regulated not only by cell proliferation and differentiation, but also by programmed cell death, or apoptosis. In response to various stimuli, death factors bind to their respective receptors and activate the apoptotic death program in target cells.
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Expression of Fas‐Fas Ligand in Murine Testis

American Journal of Reproductive Immunology, 1999
Xu JP, Li X, Mori E, Guo MW, Matsuda I, Takaichi H, Amano T, Mori T. Expression of Fas‐Fas ligand in murine testis. AJRI 1999; 42:381–388 © Munksgaard, CopenhagenPROBLEM: During spermatogenesis, it has been suggested that the number of germ cells to be matured is regulated and restricted through the apoptotic mechanism.
J P, Xu, X, Li, E, Mori, M W, Guo, I, Matsuda, H, Takaichi, T, Amano, T, Mori   +7 more
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Targeting the Fas/Fas ligand pathway in cancer

Expert Opinion on Therapeutic Targets, 2005
Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas ligand (FasL). Although originally described as an important regulator of peripheral immune homeostasis, accumulating evidence suggests that the Fas/FasL system plays an important role in tumour development.
Darren I, O'Brien, Ken, Nally, Raymond G, Kelly, Terrence M, O'Connor, Fergus, Shanahan, Joe, O'Connell   +5 more
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Fas and Fas ligand: lpr and gld mutations

Immunology Today, 1995
Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and FasL, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the ...
S, Nagata, T, Suda
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