Results 161 to 170 of about 58,729 (255)

The Role of Fas Ligand in Beta Cell Destruction in Autoimmune Diabetes of NOD Mice

, 2015
Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an important role in the induction of cell death. Ligation of Fas receptors by FasL results in apoptosis of the Fas-expressing cell. Autoimmune diabetes results from β cell
Socha, L, Charlton, Brett, Silva, D, Petrovsky, Nikolai, Slattery, Robyn   +4 more
core  

Extranodal natural killer/T‐cell lymphoma: From fatal to curable

CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Abstract Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is one of the most aggressive non‐Hodgkin lymphomas characterized by NK‐cell or T‐cell origins, a geographic prevalence in Asian and South American populations, and Epstein–Barr virus (EBV) infection.
Jie Xiong, Yok‐Lam Kwong, Laurence de Leval, Shu‐Nan Qi, Choon Kiat Ong, Philippe Gaulard, Arnaud Jaccard, Steven M. Horwitz, Ye‐Xiong Li, Sai‐Juan Chen, Ritsuro Suzuki, Won Seog Kim, Wei‐Li Zhao   +12 more
wiley   +1 more source

Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes

Hepatic Medicine: Evidence and Research, 2010
Kathleen Ponzetti1, Melissa King1, Anna Gates1, M Sawkat Anwer2, Cynthia RL Webster11Department of Clinical Science, Tufts Cummings School of Veterinary Medicine, Grafton MA, USA; 2Department of Biomedical Sciences, Tufts Cummings School of Veterinary ...
Kathleen Ponzetti, Melissa King, Anna Gates, et al   +3 more
doaj  

The role of Fas and Fas ligand in apoptosis during regression of the corpus luteum

, 1997
Apoptosis, a form of physiological cell death, has been found to occur during regression of the corpus luteum (Juengel etal, 1993; Dharmarajan etal, 1994). The pathways involved in this process, however, have yet to be specified. One possible mediator of
Roughton, Sharon
core  

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Expression of fas ligand and fas in primary cultured human astrocytes

, 1999
의학과/박사[한글] 성상교세포는 중추신경계내에 가장 많은 수를 차지하는 세포로서 다양한 생리학적기능과 중추신경계내 면역학적인 활성을 담당하며, 여러 신경계 질환에서 성상교세포는 활성화되어 질병의 진행 과정에 관여할 것으로 여겨지고 있으며, 이 과정에 세포고사가 많은 부분을 차지할 것으로 생각된다. 세포고사는 세포의 종류에 따라 다양한 자극에 의해 유발될 수 있으며, 특이한 리간드-수용기를 통해서도 유도된다.
최철희
core  

Targeting KasA: isosakuranetin derivatives as promising scaffolds for novel anti-tuberculosis agents against drug-resistant <i>Mycobacterium tuberculosis</i>. [PDF]

Front Bioinform
Angitha B, Amritha T, Dev RR, Raju R, Umesh CV, Abhithaj J.   +5 more
europepmc   +1 more source

Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD

, 2000
Jun kinase signaling can be elicited by death receptor activation, but the mechanism and significance of this event are still unclear. It has been reported that cross-linking Abs to Fas trigger c-Jun N-terminal kinase (JNK) signaling via caspase-mediated
Huang, D. C., Tschopp, J., Villunger, A., Holler, N., Strasser, A.   +4 more
core  

In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications. [PDF]

Sci Rep
Islam MS, Mollah MMH, Ahsan MA, Ali M, Al Noman M, Ahmed MF, Latif MA, Pal NK, Faysal MF, Mollah MNH.   +9 more
europepmc   +1 more source

A dynamic transcriptome technique for transcriptional profiling and gene regulatory network involving the helicase antigen (HAGE)

, 2010
Increased knowledge into the molecular pathways disrupted in tumours has led to the development of various therapies that can target specific mediators of these cascades.
Linley, AJ
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