Results 171 to 180 of about 287,562 (282)

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion <i>via</i> Dual-pathway Apoptosis and ERK/STAT3/NF-κB Inactivation. [PDF]

In Vivo
Wu CH, Hsu FT, Chen CH, Wang PE, Huang HY, Hsieh LL, Chen CH.   +6 more
europepmc   +1 more source

Engineering an Anaerobic Microenvironment to Empower Hydrogenase‐Catalyzed Hydrogen Therapy for Diabetic Wound Healing

Aggregate, Volume 7, Issue 2, February 2026.
A smart peptide hydrogel integrated with light‐responsive silver nanoclusters establishes a localized anaerobic niche, enabling hydrogenase function in oxygen‐rich biological environments. The system achieves sustained visible‐light‐driven H2 production, effectively scavenges reactive oxygen species, modulates immune responses, and significantly ...
Haishuo Ji, Yaling Wang, Kexin Yao, Junjie Li, Hang Luo, Wangzhe Li, Yanxin Gao, Wenjin Li, Qi Xiao, Tin Pou Lai, Chunxiao Chen, Xueying Li, Qian Peng, Chunqiu Zhang, Baofa Sun, Liyun Zhang   +15 more
wiley   +1 more source

<i>Curcumol</i> alleviates endometriosis via correcting the aberrant activation of Fas/RIPK1-mediated PANoptosis. [PDF]

Front Pharmacol
Ni W, Wu X, Feng L, Xu M, Tian Y.
europepmc   +1 more source

Mapping Collective Forces of Lung Cancer Spheroids Using Traction Force Microscopy

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 449-464, February 2026.
The application of conventional TFM to cancer spheroids revealed not only a size‐dependent traction force when spheroids were in non‐wetting transition state, but also a positive correlation of this force with the spheroid dispersion capacity. Moreover, the onset of spheroid dispersion was accompanied by a pronounced suppression of spheroid traction ...
Qing Zhang, Jiaqi Chen, Zhaoxu Zhang, Weili Liu   +3 more
wiley   +1 more source

Swainsonine Protects Human Thyrocytes from Fas-Induced Apoptosis: In vitro Study on Nthy-Ori 3-1 Cell Line. [PDF]

J Inflamm Res
Trzos S, Opydo M, Bochenek M, Link-Lenczowski P, Pocheć E.   +4 more
europepmc   +1 more source

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Curcuminoids remain one of the most studied dietary polyphenols as a cancer prevention and treatment agent. Inflammation and tumor progression are related to the NF‐κB signaling pathway, which is also suppressed by curcuminoids. Curcuminoids prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF‐kB pathways ...
Ushna Momal, Muhammad Shahbaz, Asfa Perween, Muhammad Hammad ul Hassan, Hammad Naeem, Zubda Shahid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Tadesse FentaYehuala, Samy Selim, Ehab M. Mostafa   +14 more
wiley   +1 more source

Endothelial Cell Regulation of Lipid Uptake During Feeding and Fasting. [PDF]

Arterioscler Thromb Vasc Biol
Goldberg IJ, Tirumalasetty M, Peche VS, Gaballa R, Cabodevilla AG, Komack M, Miao QR, Abumrad NA.   +7 more
europepmc   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Lipid-Protein Interplay in the Regulation of Receptor Tyrosine Kinases. [PDF]

Cells
Domenichini M, Gogna A, Maggi C, Moreschi E, Ventura A, Codibue M, Grillo E, Corsini M, Mitola S.   +8 more
europepmc   +1 more source