Results 71 to 80 of about 184,173 (204)
The convergence of radiation and immunogenic cell death signaling pathways. [PDF]
, 2012 Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H +4 more
core +2 more sources
Respiratory Research, 2005 Background Fas receptor-mediated eosinophil apoptosis is currently forwarded as a mechanism resolving asthma-like inflammation. This view is based on observations in vitro and in airway lumen with unknown translatability to airway tissues in vivo.
Persson Carl GA +3 more
doaj +1 more source
Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair [PDF]
, 2017 High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and
Guilak, Farshid +3 more
core +2 more sources
Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. [PDF]
PLoS ONE, 2009 Avicins, a family of triterpene electrophiles originally identified as potent inhibitors of tumor cell growth, have been shown to be pleiotropic compounds that also possess antioxidant, anti-mutagenic, and anti-inflammatory activities.
Zhi-Xiang Xu +4 more
doaj +1 more source
AIMS Medical Science, 2022 <abstract> <p>Soluble Fas ligand (sFasL, sCD95L) and its specific soluble binders, soluble Fas receptor (sFas, sCD95) and decoy receptor 3 (DcR3), have been investigated as possible clinical biomarkers in many serious diseases. The present review aimed to provide an overview of the current state of this medically promising research by ...
openaire +1 more source
Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand [PDF]
Journal of Biological Chemistry, 1997 The Fas receptor is a member of a family of cell death receptors, including tumor necrosis factor receptor I (TNFR I), death receptor 3 and 4 (DR3 and DR4), and cytopathic avian receptor 1 (CAR1). The Fas receptor is composed of several discrete domains, including three cysteine-rich domains (CRDs), a transmembrane domain, and an intracellular domain ...
J R, Orlinick +3 more
openaire +2 more sources
The Role of GLI-1 in Endocrine Resistant Breast Cancer [PDF]
, 2014 Estrogen receptor positive (ER+) and estrogen receptor negative (ER-) are two major types of breast cancer. For women with ER+ positive breast cancer, patients are treated with the antiestrogenic compounds, tamoxifen or faslodex for five years ...
Rudolph, Mark
core
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]
, 2014 In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V +13 more
core +3 more sources
The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors
Frontiers in Cell and Developmental Biology, 2020 Receptors in the tumor necrosis factor receptor superfamily (TNFRSF) regulate proliferation of immune cells or induce programmed cell death, and many of them are candidates for antibody-based immunotherapy.
Linlin Zhao +4 more
doaj +1 more source
FAS mediates apoptosis, inflammation, and treatment of pathogen infection
Frontiers in Cellular and Infection MicrobiologyThe FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL.
Liying Hu +16 more
doaj +1 more source