Results 81 to 90 of about 1,390,716 (291)
Fas induces apoptosis in human coronary artery endothelial cells in vitro
BMC Cell Biology, 2004 Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi +5 more
doaj +1 more source
Characterization of Bone Structure in Leptin Receptor-Deficient Zucker (fa/fa) Rats
Journal of Bone and Mineral Research, 2003 Abstract To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor-deficient Zucker rat was examined using pQCT, μCT, and histomorphometry. A trend toward decreasing structural and bone formation parameters in these rats as they age suggest that leptin has a small positive effect on bone.
Joseph A, Tamasi +3 more
openaire +2 more sources
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
T-cell receptor complex is essential for Fas signal transduction
, 2010 The Fas receptor (also known as CD95 and APO-1) is a member of the tumor necrosis factor α-family of death receptors that mediate T-cell responses. Here, we show that Fas receptor signaling requires a functional T-cell receptor (TCR) complex.
Jiaren Sun +3 more
core +1 more source
Advanced Science, EarlyView.Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou +11 more
wiley +1 more source
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
FAS mediates apoptosis, inflammation, and treatment of pathogen infection
Frontiers in Cellular and Infection MicrobiologyThe FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL.
Liying Hu +16 more
doaj +1 more source
The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors
Frontiers in Cell and Developmental Biology, 2020 Receptors in the tumor necrosis factor receptor superfamily (TNFRSF) regulate proliferation of immune cells or induce programmed cell death, and many of them are candidates for antibody-based immunotherapy.
Linlin Zhao +4 more
doaj +1 more source
AIMS Medical Science, 2022 <abstract> <p>Soluble Fas ligand (sFasL, sCD95L) and its specific soluble binders, soluble Fas receptor (sFas, sCD95) and decoy receptor 3 (DcR3), have been investigated as possible clinical biomarkers in many serious diseases. The present review aimed to provide an overview of the current state of this medically promising research by ...
openaire +1 more source
Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis
, 2004 Prolonged use of glucocorticoids is associated with decreased bone formation, increased resorption and osteonecrosis, through direct and indirect effects on the activity and viability of bone effector cells, osteoblasts and osteoclasts, and osteocytes ...
Noble, B. +6 more
core +1 more source