A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]
, 2015 Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E +15 more
core +2 more sources
From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies
Portal Hypertension &Cirrhosis, EarlyView.This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu +5 more
wiley +1 more source
Advanced Science, 2022 Neutrophils constitute abundant cellular components in human gastric cancer (GC) tissues, but their protumorigenic subset in pathogenesis of GC progression is unclear.
Zhi‐Guo Shan +14 more
doaj +1 more source
Diverse immunological roles of liver‐resident immune cells in liver diseases
Precision Medical Sciences, EarlyView.Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan +4 more
wiley +1 more source
Functional polymorphisms in FAS/FASL system increase the risk of neuroblastoma in Chinese population. [PDF]
PLoS ONE, 2013 The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells. Three polymorphisms located in the promoter regions of FAS (-1377G/A and -670A/G) and FASL (-844T/C) have been shown to alter the transcriptional activity of the ...
Wei Han +18 more
doaj +1 more source
In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]
, 2009 FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles +2 more
core +5 more sources
Platelets induce apoptosis via membrane-bound FasL
Blood, 2015 Key PointsPLTs contribute to apoptosis in vivo and express the death receptor ligand FasL upon activation. Membrane-bound FasL mediates PLT-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces PLT-induced apoptosis.
Schleicher, Rebecca I. +20 more
openaire +4 more sources
Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management
Rheumatology &Autoimmunity, EarlyView.Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley +1 more source
Impaired fas-fas ligand interactions result in greater recurrent herpetic stromal keratitis in mice [PDF]
, 2015 Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a ...
Chelsea R. Del Rosso +7 more
core +9 more sources
Construction of FasL siRNA expression vector and its expression in lung cancer cell line A549
Chinese Journal of Lung Cancer, 2008 Background and objective Fas/FasL is a member of Tumor Necrosis Factor (TNF) super family and related to tumor cell apoptosis. It is hypothesis by forward study that activated lymphocytes is more sensitive with Fas/FasL due to up-regulation of FasL ...
Bo DENG +4 more
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