Results 21 to 30 of about 19,057 (240)
Osteocytic Connexin43 Channels Regulate Bone–Muscle Crosstalk
Cells, 2021 Bone–muscle crosstalk plays an important role in skeletal biomechanical function, the progression of numerous pathological conditions, and the modulation of local and distant cellular environments. Previous work has revealed that the deletion of connexin
Guobin Li +7 more
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JOR Spine, 2022 Background Adolescent idiopathic scoliosis (AIS) refers to a three‐dimensional spinal deformity which has a typical onset during adolescence. In most cases, the cause of the deformity cannot be clearly identified. Unbalanced paraspinal muscle activity in
Wai Kit Tam +5 more
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Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
Skeletal Muscle, 2021 Background The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscle. Six1 also contributes to muscle metabolism and its activity is associated with the fast-twitch, glycolytic phenotype ...
John Girgis +4 more
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Regulation of Force Dynamics in Fast Twitch Muscle
The FASEB Journal, 2010 Several regulatory steps controlling skeletal muscle force generation have been experimentally demonstrated, and mathematical models have been developed to understand these mechanisms. Here, we investigated the minimal set of mechanisms required to describe both the range in peak force from twitch to tetanus ...
Groenendaal, W. +5 more
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Frontiers in Physiology, 2021 Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis, autoimmune neuritis and muscular dystrophy.
Leonit Kiriaev +6 more
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KMT5B is required for early motor development
Frontiers in Genetics, 2022 Disruptive variants in lysine methyl transferase 5B (KMT5B/SUV4-20H1) have been identified as likely-pathogenic among humans with neurodevelopmental phenotypes including motor deficits (i.e., hypotonia and motor delay). However, the role that this enzyme
Jason Hulen +9 more
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Frontiers in Physiology, 2020 Reduced Cl− conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita.
Kerstin Hoppe +14 more
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Life, 2023 The ratio of fast- and slow-twitch fibers in human skeletal muscle is variable and largely determined by genetic factors. In this study, we investigated the contribution of microRNA (miRNA) in skeletal muscle fiber type composition.
Andrey V. Zhelankin +4 more
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Piperine enhances contractile force in slow‐ and fast‐twitch muscle [PDF]
The Journal of PhysiologyAbstractPiperine has been shown to bind to myosin and shift the distribution of conformational states of myosin molecules from the super‐relaxed state to the disordered relaxed state. However, little is known about the implications for muscle force production and potential underlying mechanisms.
Jon Herskind +4 more
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Loss of fast-twitch isomyosins in skeletal muscles of the diabetic rat [PDF]
Biochemical Journal, 1984 By means of pyrophosphate electrophoresis the myosin isoenzyme pattern of two fast-twitch skeletal muscles (extensor digitorum longus, gastrocnemius) and one slow-twitch muscle (soleus) was investigated in control rats and was compared with that of rats 4 weeks after induction of diabetes mellitus by streptozotocin injection. In the fast-twitch muscles
M, Rutschmann, B, Dahlmann, H, Reinauer
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