Results 61 to 70 of about 19,057 (240)

Paroxysmal slow waves mark ictal networks

Epilepsia, EarlyView.
Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé, Hamza Imtiaz, Ofer Prager, Evyatar Swissa, Alaa Abu Ahmad, Yonatan Serlin, Refat Aboghazleh, Ilan Goldberg, Maayan Ben nun Caller, Idit Tamir, Oded Shor, Ben Whatley, Felix Benninger, Alon Friedman   +13 more
wiley   +1 more source

Structure of the rabbit fast-twitch skeletal muscle calsequestrin gene.

Journal of Biological Chemistry, 1988
We have isolated two overlapping 17-kilobase (kb) genomic clones which, together, encode the rabbit fasttwitch skeletal muscle calsequestrin. The calsequestrin gene is 8.6 kb in length and consists of 11 exons. Sl nuclease protection and primer extension analyses position the transcription initiation site 191 nucleotides upstream of the translation ...
Zarain-Herzberg, A., Fliegel, Larry, MacLennan, D. H.   +2 more
openaire   +3 more sources

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Six-week combined exercise modulates mitochondrial dynamics (MFN1/DRP1) and oxidative stress (MDA/SOD) in fast- and slow-twitch muscles of aged rats [PDF]

Journal of Exercise & Organ Cross Talk
Aging is associated with mitochondrial dysfunction, which leads to decreased cellular function and the development of age-related diseases. Exercise training is considered one of the most effective strategies for improving muscle cell function.
Sina Gholaminezhad Kolachahi, Farhad Rahmani-nia, Mohammad Reza Fadaei Chafy   +2 more
doaj   +1 more source

Effect of exercise‐related nasopharyngeal disorders on upper airway function in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Exercise‐related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings. Objectives To objectively investigate how palatal instability (PI), intermittent dorsal displacement of the ...
Hanna Vermedal, Ingunn Risnes Hellings, Zoe L. Fretheim‐Kelly, Constanze Fintl, Eric Strand   +4 more
wiley   +1 more source

Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

Scientific Reports
Skeletal muscle is a highly heterogeneous tissue, and its contractile proteins are composed of different isoforms, forming various types of muscle fiber, each of which has its own metabolic characteristics.
Jialin Li, Sheng Zhang, Can Li, Xiaoxia Zhang, Yuhui Shan, Ziyi Zhang, Hai Bo, Yong Zhang   +7 more
doaj   +1 more source

Longevity of cardiac and skeletal muscle proteins is dependent on tissue and subcellular compartmentation patterns

Cell Reports
Summary: Myocytes are exceptionally long-lived cells that must maintain proteome integrity over decades while adjusting for changes in functional output and metabolic demand.
Jack Gugel, Jordan Currie, Lorena Alamillo, Jason Flint, Keun-Young Kim, Marc Debliqui, Mark H. Ellisman, Maggie P.Y. Lam, Edward Lau, Rafael Arrojo e Drigo, Leslie Leinwand   +10 more
doaj   +1 more source