Results 31 to 40 of about 2,648 (261)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Research Status and Development of Low-alloy High-strength Fastener Steel [PDF]
TeshugangLow-alloy high-strength fastener stee which is widely used in automobiles， high-speed rail， aviation， aerospace， defense， and other fields due to its excellent mechanical properties and in line with the trend of lightweight development.
Zhang Ming, Zhang Jianfeng, Lin Zaiyong
doaj +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Fastener design development technology for warship equipment installation based on IDEF0
Zhongguo Jianchuan Yanjiu, 2017 [Objectives] In order to improve the efficiency and quality of fastener design during equipment installation,in combination with the construction design of warships, [Methods] the design flow of fasteners for warship equipment installation is described ...
LU Yongjin
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Metals, 2019 Hi-Lok fasteners were subjected to multiple collar replacements, and were tested under static loading and constant-amplitude fatigue loading, to determine the effect of repetitive collar replacement on the residual strength and fatigue life of a retained
David F. Hardy, David L. DuQuesnay
doaj +1 more source
npj Materials Degradation, 2023 The synergistic effect of crevice corrosion and galvanic coupling on the degradation of 304 stainless steel fasteners exposed to a chloride environment was investigated using electrochemical and surface analysis techniques. Results obtained revealed that
Enobong Felix Daniel +8 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Investigation Of Different Fasteners In Roof Truss Elements In The Woodworking Industry
Turkish Journal of ForestryIn this study, the compressive safety stresses of the roof trusses were determined depending on the different joining angles (90° at the rafter, 90° at the base and bisector) at the connection points of the rafter and base elements used in traditional ...
Mert Arslan +7 more
doaj +1 more source