Results 31 to 40 of about 8,890 (312)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Mechanical and Deformation Response of WJ-8B Rail Fastener Under Cyclic Lateral Loading

open access: yesBuildings
The mechanical performance of rail fasteners plays a crucial role in the track–structure interaction of high-speed railways. A reasonable lateral stiffness of the fastener system can enhance the stability and safety of train operation and prevent ...
Fengyu Zhang   +3 more
doaj   +1 more source

Fastener Pattern Optimization of an Eccentrically Loaded Multi-Fastener Connection

open access: yes, 2010
This paper presents the use of a genetic algorithm in conjunction with geometric nonlinear finite element analysis to optimize the fastener pattern and lug location in an eccentrically loaded multi-fastener connection.
Mark Jakiela, Matthew Watkins
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Parameters Influence of New Particle Damper-based Fastener on its Damping Ratio

open access: yesChengshi guidao jiaotong yanjiu
[Objective] Fastener stiffness and damping are important factors affecting rail system vibration and wheel-rail noise, especially the fastener damping can directly affects the high frequency attenuation rate of the rail structure (rail noise) and the ...
YAO Yuyang   +3 more
doaj   +1 more source

Fastener design development technology for warship equipment installation based on IDEF0

open access: yesZhongguo Jianchuan Yanjiu, 2017
[Objectives] In order to improve the efficiency and quality of fastener design during equipment installation,in combination with the construction design of warships, [Methods] the design flow of fasteners for warship equipment installation is described ...
LU Yongjin
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Effect of Repetitive Collar Replacement on the Residual Strength and Fatigue Life of Retained Hi-Lok Fastener Pins

open access: yesMetals, 2019
Hi-Lok fasteners were subjected to multiple collar replacements, and were tested under static loading and constant-amplitude fatigue loading, to determine the effect of repetitive collar replacement on the residual strength and fatigue life of a retained
David F. Hardy, David L. DuQuesnay
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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