Results 51 to 60 of about 8,890 (312)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Regression Method for Rail Fastener Tightness Based on Center-Line Projection Distance Feature and Neural Network

Chinese Journal of Mechanical Engineering
In the railway system, fasteners have the functions of damping, maintaining the track distance, and adjusting the track level. Therefore, routine maintenance and inspection of fasteners are important to ensure the safe operation of track lines. Currently,
Yuanhang Wang, Duxin Liu, Sheng Guo, Yifan Wu, Jing Liu, Wei Li, Hongjie Wang   +6 more
doaj   +1 more source

Toe Load Detection and Test Verification Based on the Natural Frequency of Fastener Elastic Rod

Chengshi guidao jiaotong yanjiu
Objective The insufficient toe load of the fastener elastic rod will induce loosening of the surrounding fasteners, aggravate the dynamic response between wheels and rails, affecting the service life of the track components. Compared with the missing and
DING Zhengxiang, CAO Ziwen, LIU Mingjia, LIU Linya, WEI Zheng, HU Zhequan, SONG Rui   +6 more
doaj   +1 more source

Discrete ply model of circular pull-through test of fasteners in laminates [PDF]

, 2012
In aeronautical structures, assemblies with thin laminates are becoming increasingly usual, especially for fuselage design. In these structures, out-of-plane loads can appear in bolted joints and can lead to progressive punching of the fastener’s head in
Bouvet, Christophe, Adam, Louis, Castanié, Bruno, Bonhomme, Elodie, Daidié, Alain   +4 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A fusion of attention and multi-task learning approach for surface quality prediction in turning [PDF]

AIP Advances
Surface quality is a critical indicator of mechanical part performance and service life, encompassing surface roughness, dimensional accuracy, and roundness.
Wen Cheng, Yan Cao, Weitao Dou, Heyuan Tian   +3 more
doaj   +1 more source

Hame Fastener.

, 1885
Patent for a new and improved hame-fastener. This design "consists of an adjustable regulating fastener for the upper and lower ends of the hames, and this fastener is further provided with a swinging loop, to which the breast-strap may be attached on ...
Hake, Francis A.
core  

Fastener [PDF]

, 2000
A fastener body comprises a head and a shank fabricated from a composite material. The head has at least one side which extends beyond the side of the shank and has two other sides coplanar with the shank.
Miller, Robert J., Moree, Jeffery C., Jarmon, David C.   +2 more
core