Results 61 to 70 of about 2,648 (261)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Experimental Study on Bearing Capacity of Reinforced Steel Tubular Scaffold under Uniform Loads
Advances in Civil Engineering, 2019 Five groups of tests were designed to analyze the influence of node types (fastener connection and mortise-and-tenon joint) and reinforcement modes of top horizontal cross rods (weak truss and stiffening truss) on the bearing capacity of the steel ...
Li Jia +4 more
doaj +1 more source
Sensors, 2018 With the increase in the number of service years for high-speed railways, the foundation of the rail track suffers from settlement, which causes rail track irregularity.
Hao Cui, Qingwu Hu, Qingzhou Mao
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Experimental study on response of carbon fiber composite with fasteners under lightning strike
Hangkong gongcheng jinzhanComposite is widely used in aircraft structure, and its lightning protection methods are becoming increasingly mature, but the research on conducted lightning current at the joint of metal fasteners and composite is still incomplete.
YAO Junjun, LI Dan, HE Zheng, XIONG Xiu
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Engineering Verification of Key Technologies for Rail Transit Stray Current Protection
Chengshi guidao jiaotong yanjiu[Objective] In order to solve the problem of stray current corrosion on metro lines, it is necessary to conduct engineering verification of the key technologies for stray current protection in urban rail transit.
JIN Shoujie +5 more
doaj +1 more source