Results 71 to 80 of about 8,890 (312)
, 1912 Patent for a sash fastener. The invnetion is designed to be of durable use as a window sash fastener.
Flaniken, William F.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Experimental study on response of carbon fiber composite with fasteners under lightning strike
Hangkong gongcheng jinzhanComposite is widely used in aircraft structure, and its lightning protection methods are becoming increasingly mature, but the research on conducted lightning current at the joint of metal fasteners and composite is still incomplete.
YAO Junjun, LI Dan, HE Zheng, XIONG Xiu
doaj +1 more source
Fastener region location method based on gray-scale mutation
Journal of Measurement Science and Instrumentation, 2021 Rail fastener positioning method has high requirements for image quality and positioning accuracy. Therefore, a rail fastener positioning method based on gray mutation is proposed. Firstly, the image is denoised by an improved median filter.
Lü Banghuan, MIN Yongzhi, HUO Hongtao
doaj
Delayed Metallic Embolization of a Cor-Knot Fastener
The Thoracic & Cardiovascular Surgeon Reports, 2017 Background The Cor-Knot device is a titanium fastener which is widely used in cardiac valve procedures. Adverse events associated with use of the device have been rare.
H. Edward Garrett Jr.
doaj +1 more source
, 2002 A captive fastener device is utilized to hold two members together. The device is comprised of a housing which may be securely attached to the first member. Within the housing is a spring which biases a bottom of a first lip of a cup washer.
Dowling, Timothy Edward
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Experimental Study on Bearing Capacity of Reinforced Steel Tubular Scaffold under Uniform Loads
Advances in Civil Engineering, 2019 Five groups of tests were designed to analyze the influence of node types (fastener connection and mortise-and-tenon joint) and reinforcement modes of top horizontal cross rods (weak truss and stiffening truss) on the bearing capacity of the steel ...
Li Jia +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source