Frontiers in Physiology, 2021 In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue (VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM), cardiovascular disease, and non-alcoholic fatty liver disease ...
Kristoffer Jensen Kolnes +4 more
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Physiological process of fat loss [PDF]
Bulletin of the National Research Centre, 2019 Background Adipose tissue is a type of connective tissue composed of adipocytes. Recently, this tissue has been recognized as a major endocrine organ. The physiological process of fat loss occurs when fats are liberated from adipocytes into circulation ...
Salwa Refat El-Zayat +2 more
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Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. [PDF]
Cell Res, 2023 Obesity imposes a global health threat and calls for safe and effective therapeutic options. Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which was largely attributed to dietary cysteine intake ...
Song T +9 more
europepmc +2 more sources
Sustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice. [PDF]
J Inflamm Res, 2022 Background Sustained inflammation is implicated in a variety of pathological conditions like infection, obesity and type 2 diabetes. Lipid metabolism is crucial to support immune response during infection of bacteria.
Yang Y +9 more
europepmc +2 more sources
GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates. [PDF]
Nat CommunGlucagon-like peptide-1 receptor agonists act via appetite suppression and caloric restriction. These treatments can result in significant muscle loss, likely due to evolutionary mechanisms protecting against food scarcity as muscle is a major energy ...
Mastaitis JW +11 more
europepmc +2 more sources
The Effects of Time-Restricted Eating on Fat Loss in Adults with Overweight and Obese Depend upon the Eating Window and Intervention Strategies: A Systematic Review and Meta-Analysis. [PDF]
NutrientsTime-restricted eating (TRE) is a circadian rhythm-based intermittent fasting intervention that has been used to treat obesity. However, the efficacy and safety of TRE for fat loss have not been comprehensively examined and the influences of TRE ...
Xie Y, Zhou K, Shang Z, Bao D, Zhou J.
europepmc +2 more sources
Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism. [PDF]
Mol MetabObjective Glucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing remarkable weight loss in overweight and obese individuals.
Nunn E +11 more
europepmc +2 more sources
High-Intensity Intermittent Exercise and Fat Loss [PDF]
Journal of Obesity, 2011 The effect of regular aerobic exercise on body fat is negligible; however, other forms of exercise may have a greater impact on body composition. For example, emerging research examining high-intensity intermittent exercise (HIIE) indicates that it may ...
Stephen H. Boutcher
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Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia
Non-coding RNA Research, 2021 Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss.
Guannan Du +4 more
doaj +3 more sources
Nutrients, 2020 Background: The rise in obesity has emphasised a focus on lifestyle and dietary habits. We aimed to address the debate between low-carbohydrate and low-fat diets and compare their effects on body weight, low-density lipoprotein cholesterol (LDL), high ...
Dina Radenkovic +2 more
exaly +2 more sources