Results 101 to 110 of about 401,489 (268)

Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1

The EMBO Journal
The role of long non-coding RNAs (lncRNAs) in early mammalian embryogenesis remains unclear due to the complexity of the regulatory mechanisms involving lncRNAs and the limited availability of embryo samples.
Arianna Coppola, Filomena Amoroso, Federica Saracino, Gennaro Andolfi, Edoardo Sozzi, Paolo Salerno, Pietro Zoppoli, Alessandro Fiorenzano, Giuseppe Merla, Eduardo Jorge Patriarca, Gabriella Minchiotti, Annalisa Fico   +11 more
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

SIMULACIÓN DE COEXTRUSIÓN DE CAUCHO POR ELEMENTOS FINITOS PARA EL DISEÑO DE MATRICES EN LA INDUSTRIA DEL NEUMÁTICO

Anales (Asociación Física Argentina), 2015
En la industria del neumático una de las áreas de trabajo principales es la de extrusión. Mediante este proceso se producen distintos tipos de semielaborados que luego van a conformar la cubierta cruda (rodados, costados, etc). Durante la extrusión, los
B Toscano, T Arechaga
doaj  

Degradable, Skin‐Conformal Nanocomposite‐Based Bioelectronic Patches for High‐Fidelity Electrophysiology and Gesture‐Controlled Robotics

Advanced Functional Materials, EarlyView.
A degradable, skin‐conformal bioelectronic patch combines a starch‐dominated nanocomposite conductor with a gelatin substrate to enable sensitive strain sensing, high‐fidelity electrocardiography, electromyography, electrooculography, and machine‐learning‐assisted gesture control.
Ming Dong, Hongna Yuan, Shubo Liu, Abdulkadir Sanli, Emiliano Bilotti, Han Zhang, Pietro Cataldi, Karin Hing, Oliver Fenwick, Colin J. Humphreys, Dimitrios G. Papageorgiou   +10 more
wiley   +1 more source

Nanoamphizymes: Self‐Assembled Amphiphilic Enzymatic Nanomaterials for High‐Performance Biocatalysis and Biosensing

Advanced Functional Materials, EarlyView.
An amphiphilic GOx nanoamphizyme was constructed by covalently introducing hydrophobic PPNI linkers onto GOx, enabling spontaneous self‐assembly into tunable nanoparticles. Mild crosslinking further stabilized the assemblies and enhanced catalytic performance and stability.
Yuan‐Hao Hsiao, Rajan Deepan Chakravarthy, Po‐Hsiang Chen, Abdelreheem Abdelfatah Saddik, Hsin‐Chieh Lin   +4 more
wiley   +1 more source

Mitotic chromatin marking governs the segregation of DNA damage

Nature Communications
The faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations.
Juliette Ferrand, Juliette Dabin, Odile Chevallier, Matteo Kane-Charvin, Ariana Kupai, Joel Hrit, Scott B. Rothbart, Sophie E. Polo   +7 more
doaj   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells

Cell & Bioscience
Background Numerous studies have shown that somite development is a necessary stage of myogenesis chondrogenesis and osteogenesis. Our previous study has established a stable presomitic mesoderm progenitor cell line (UiPSM) in vitro. Naturally, we wanted
Huiru Gao, Xingnan Huang, Zepo Cai, Baomei Cai, Kaipeng Wang, Junyang Li, Junqi Kuang, Bo Wang, Ziwei Zhai, Jin Ming, Shangtao Cao, Yue Qin, Duanqing Pei   +12 more
doaj   +1 more source

Rare‐Earth–Functionalized Carbon Dot Hydrogels as Mechanically Robust Antibacterial Wound Dressings

Advanced Healthcare Materials, EarlyView.
The schematic depicts a dynamically cross‐linked PVA hydrogel network in which reversible borate ester bonds and hydrogen‐bonding interactions integrate lanthanum‐doped carbon dots (La‐CDs) and dipotassium glycyrrhizinate (DPG) to form a mechanically robust, multifunctional matrix.
Shih‐Han Tsai, Ramadhass Keerthika Devi, Muthusankar Ganesan, Guo‐Ping Chang Chien, Chun Che Lin   +4 more
wiley   +1 more source