Results 91 to 100 of about 1,264,513 (255)
Engineering mouse cell fate controller by rational design
Nature CommunicationsCell fate is likely regulated by a common machinery, while components of this machine remain to be identified. Here we report the design and testing of engineered cell fate controller NanogBiD, fusing BiD or BRG1 interacting domain of SS18 with Nanog ...
Tao Huang +16 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
ESTUDIO Y CARACTERIZACIÓN DE MODOS NORMALES EN NEUMÁTICOS PARA VEHÍCULOS DE PASAJEROS
Anales (Asociación Física Argentina), 2014 Se analizaron las frecuencias naturales de vibración mediante análisis modal con martillo instrumentado para dos neumáticos radiales de automóvil de distintas medidas.
M E Dalmau +3 more
doaj
Fate of Zero-Temperature Ising Ferromagnets
, 2000 We investigate the relaxation of homogeneous Ising ferromagnets on finite lattices with zero-temperature spin-flip dynamics. On the square lattice, a frozen two-stripe state is apparently reached approximately 1/4 of the time, while the ground state is ...
A. Lipowski +16 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy
Nature CommunicationsIntracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp.
Marie Villares +15 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Sticking Together Because We're Stuck Together: Solidarity, Indivisibility, and Collective Action in the European Union [PDF]
, 2011 Starting from the premise that popular support is increasingly a necessary condition for European Union initiatives, this paper utilizes the concept of solidarity to attempt to better specify the nature of “we feeling” in Europe and its relationship to ...
Fogarty, Edward A.
core
The Fate of the Accelerating Universe
, 2005 The presently accelerating universe may keep accelerating forever, eventually run into the event horizon problem, and thus be in conflict with the superstring idea.
A. R. Liddle +4 more
core +1 more source
SciPost PhysicsQuantum entanglement manifests itself in non-local correlations between the constituents of a system. In its simplest realization, a measurement on one subsystem is affected by a prior measurement on its partner, irrespective of their separation. For multiple parties, purely collective types of entanglement exist but their detection, even theoretically,
Gilles Parez, William Witczak-Krempa
openaire +2 more sources