Results 71 to 80 of about 1,264,513 (255)

Channelrhodopsins with distinct chromophores and binding patterns

Nature Communications
Channelrhodopsins are popular optogenetic tools in neuroscience, but remain poorly understood mechanistically. Here we report the cryo-EM structures of channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii and H.
Yuanyue Shan, Liping Zhao, Meiyu Chen, Xiao Li, Mingfeng Zhang, Duanqing Pei   +5 more
doaj   +1 more source

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Quantifying sources of variability in neonicotinoid residue data for assessing risks to pollinators

Julius-Kühn-Archiv, 2018
The U.S. Environmental Protection Agency’s 2014 guidance for assessing pesticide risks to bees relies on higher-tier studies of residues in pollen and nectar to refine pesticide exposure estimates obtained from lower tier information (e.g., default ...
Sappington, Keith, Mroz, Ryan, Garber, Kris, Farruggia, Frank, Wagman, Michael, Blankinship, Amy, Koper, Chris   +6 more
doaj   +1 more source

Fate of $Z_2$ Symmetric Scalar Field

, 2013
The evolution of a coherently oscillating scalar field with $Z_2$ symmetry is studied in detail. We calculate the dissipation rate of the scalar field based on the closed time path formalism.
Mukaida, Kyohei, Nakayama, Kazunori, Takimoto, Masahiro   +2 more
core   +1 more source

Spatiotemporal visualization of subcellular dynamics of carbon nanotubes [PDF]

, 2012
To date, there is no consensus on the relationship between the physicochemical characteristics of carbon nanotubes (CNTs) and their biological behavior; however, there is growing evidence that the versatile characteristics make their biological fate ...
Baba, Yoshinobu, Bianco, Alberto, Braeckmans, Kevin, Habuchi, Satoshi, Kaji, Noritada, Serag, Maged F   +5 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Spontaneous whole genome duplication renders mouse embryonic fibroblasts resistant to reprogramming

Cell & Bioscience
Whole-genome duplication (WGD) is thought to be quite rare, but has important implications ranging from emergences of new species to tumorigenesis. The burden of doubled genome for a cell must be traumatic and remains poorly understood.
Wei Li, Lingyu Zhong, Pengli Li, Ziwei Zhai, Runxia Lin, Minjing Ke, Yixin Fan, Yu Liu, Yu Fu, Yue Qin, Chengchen Zhao, Bo Wang, Junqi Kuang, Duanqing Pei   +13 more
doaj   +1 more source

Tracing blastomere fate choices of early embryos in single cell culture [PDF]

, 2010
Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages.
Chang Ming Li, Haobin Zhao, Jianxin Song, Meisheng Yi, Mingyou Li, Ni Hong, Rong Liu, Ruowen Ge, Yan Yan, Yongming Yuan, Yunhan Hong, Zhendong Li   +11 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source