Results 51 to 60 of about 1,253,544 (212)

Evaporation and Fate of Dilatonic Black Holes [PDF]

, 1995
We study both spherically symmetric and rotating black holes with dilaton coupling and discuss the evaporation of these black holes via Hawking's quantum radiation and their fates.
A. A. Tseytlin, A. A. Tseytlin, A. Sen, A. Sen, C. F. E. Holzhey, C. F. E. Holzhey, C. G. Callan, C. G. Callan, C. J. Bouwkamp, C. J. Bouwkamp, D. Garfinkle, D. Garfinkle, D. S. Goldwirth, D. S. Goldwirth, E. J. Copeland, E. J. Copeland, G. Veneziano, G. Veneziano, G. W. Gibbons, G. W. Gibbons, G. W. Gibbons, G. W. Gibbons, G. W. Gibbons, G. W. Gibbons, I. Antoniadis, I. Antoniadis, J. H. Horne, J. H. Horne, J. Koga, J. Koga, Jun-Ichirou Koga, K. Maeda, K. Maeda, K. Shiraishi, K. Shiraishi, K. Shiraishi, K. Shiraishi, Kei-Ichi Maeda, S. W. Hawking, S. W. Hawking, V. Frolov, V. Frolov, W. G. Unruh, W. G. Unruh   +43 more
core   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Cell Death Discovery, 2023
Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J. Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas   +9 more
doaj   +1 more source

Tracing blastomere fate choices of early embryos in single cell culture [PDF]

, 2010
Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages.
Chang Ming Li, Haobin Zhao, Jianxin Song, Meisheng Yi, Mingyou Li, Ni Hong, Rong Liu, Ruowen Ge, Yan Yan, Yongming Yuan, Yunhan Hong, Zhendong Li   +11 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels

Nature Communications
OSCA/TMEM63 channels, which have transporter-like architectures, are bona fide mechanosensitive (MS) ion channels that sense high-threshold mechanical forces in eukaryotic cells.
Yuanyue Shan, Mengmeng Zhang, Meiyu Chen, Xinyi Guo, Ying Li, Mingfeng Zhang, Duanqing Pei   +6 more
doaj   +1 more source

Metabolic–Epigenetic Axis in Pluripotent State Transitions

Epigenomes, 2019
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling.
Cristina D’Aniello, Federica Cermola, Eduardo J. Patriarca, Gabriella Minchiotti   +3 more
doaj   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]

, 2019
Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J, Dall'Agnese, Alessandra, Duester, Gregg, Etxaniz, Usue, Latella, Lucia, Nicoletti, Chiara, Puri, Pier Lorenzo, Sacco, Alessandra, Sala, David, Stec, Michael J   +9 more
core   +3 more sources