Results 31 to 40 of about 6,843 (265)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

A damage-based method to predict crack initiation lifetime of high-strength steel under proportional bending-torsional loadings

Advances in Mechanical Engineering, 2022
The fatigue life of specimen consists of crack initiation and crack propagation life. As the fracture toughness of high strength steel is low, the specimen will fail soon once crack appears.
Ganggang Gao, Jianhui Liu, Xuebin Lu, Rong Zhang   +3 more
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

High temperature effects on fatigue performance and crack initiation mechanisms of 316LN stainless steel for nuclear power pipelines

Journal of Materials Research and Technology
This study performed high-cycle fatigue tests on 316LN stainless steel (SS) for nuclear power application to evaluate its fatigue behavior at both room temperature (RT) and 350 °C.
JianNeng Zheng, JunChao Hu, YueHui Jiang, QingYuan Wang, Kun Yang   +4 more
doaj   +1 more source

Effect of Microstructure on the High-Cycle Fatigue Behavior of Ti(43-44)Al4Nb1Mo (TNM) Alloys

Metals, 2019
To investigate the high-cycle fatigue (HCF) behavior of TNM alloys, three different microstructures were designed and obtained by different heat treatments.
Bin Tang, Bin Zhu, Weiqing Bi, Yan Liu, Jinshan Li   +4 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Influence of Residual Stresses on the Crack Initiation and Short Crack Propagation in a Martensitic Spring Steel

Metals, 2022
The crack initiation and short crack propagation in a martensitic spring steel were investigated by means of in-situ fatigue testing. Shot peened samples as well as untreated samples were exposed to uniaxial alternating stress to analyze the impact of ...
Anna Wildeis, Hans-Jürgen Christ, Robert Brandt   +2 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Crystal plasticity analysis of fatigue crack initiation site considering crystallographic orientation in Ti–22V–4Al alloy

Results in Engineering
In this study, plane bending fatigue tests were conducted on Ti–22V–4Al alloy, a β-type titanium alloy, to examine the fatigue crack initiation behavior in detail.
Jinta Arakawa, Koki Hirazumi, Takeshi Uemori, Yoshito Takemoto   +3 more
doaj   +1 more source