Results 41 to 50 of about 57,383 (312)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Initiation Characteristics of Corrosion Fatigue Crack in 18Ni (250) Steel

Journal of Marine Science and Engineering
Maraging steel is the material of deep sea pressure equipment. The characteristics of corrosion fatigue crack initiation in 18Ni (250) were investigated by performing a tensile fatigue test under different loading conditions.
Hongzhang Pan, Yongmei Zhu, Mingjiang Fang   +2 more
doaj   +1 more source

Crack Initiation and Propagation Fatigue Life of Ultra High-Strength Steel Butt Joints

Applied Sciences, 2019
The division of the total fatigue life into different stages such as crack initiation and propagation is an important issue in regard to an improved fatigue assessment especially for high-strength welded joints.
Markus J. Ottersböck, Martin Leitner, Michael Stoschka, Wilhelm Maurer   +3 more
doaj   +1 more source

Further Considerations Concerning a Mechanism of Fatigue Crack Propagation [PDF]

, 1970
X-ray microbeam diffraction technique is a useful one to investigate the features of the crystal deformation in a localized area. That is, this method have been adopted to examine the density and array of dislocation, microscopic lattice strain and ...
Honda, Kazuo, Konaga, Tetsuro
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source

Initiation of internal fatigue crack in a carbide-free bainitic steel during high cycle fatigue

Journal of Materials Research and Technology
The crack initiation stage is crucial to the overall fatigue behavior of the carbide-free bainitic steels. Through S–N curve testing and fracture observation, it is demonstrated that internal crack initiation is the dominant mode during high cycle ...
Bo Mi, Yuming Fu, Shichun Liu, Yan Wang, Zhigang Yang, Chi Zhang   +5 more
doaj   +1 more source

Mechanisms of fatigue-crack initiation and their impact on fatigue life of AlSi7 die-cast components

MATEC Web of Conferences, 2014
In the course of the present study, in-situ observations of crack initiation and crack growth of naturally induced cracks in cyclically loaded specimens along with conventional fatigue tests and fracture surface analyses were performed.
Redik Sabine, Tauscher Markus, Grün Florian   +2 more
doaj   +1 more source

A damage-based method to predict crack initiation lifetime of high-strength steel under proportional bending-torsional loadings

Advances in Mechanical Engineering, 2022
The fatigue life of specimen consists of crack initiation and crack propagation life. As the fracture toughness of high strength steel is low, the specimen will fail soon once crack appears.
Ganggang Gao, Jianhui Liu, Xuebin Lu, Rong Zhang   +3 more
doaj   +1 more source

DETERMINATION OF FATIGUE CRACK INITIATION LIFE [PDF]

Fatigue & Fracture of Engineering Materials & Structures, 1979
Abstract—A reanalysis has been carried out on the results of Zachariah. An elastic‐plastic analysis based onS‐Ndata indicates that the mechanism of growth of very small cracks is similar to that expressed by linear elastic fracture mechanics, i.e. crack growth in mild steel is given byimagewhere Δγpis the plastic shear strain range andais the crack ...
M. F. E. IBRAHIM, K. J. MILLER
openaire   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source