Results 31 to 40 of about 189,627 (255)

RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Scatophagus argus)

Animals, 2023
Spotted scat (Scatophagus argus) can tolerate a wide range of salinity fluctuations. It is a good model for studying environmental salinity adaptation. Lipid metabolism plays an important role in salinity adaptation in fish. To elucidate the mechanism of
Jieqing Chen, Bosheng Cai, Changxu Tian, Dongneng Jiang, Hongjuan Shi, Yang Huang, Chunhua Zhu, Guangli Li, Siping Deng   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii. [PDF]

PLoS ONE, 2018
Acinetobacter baumannii ATCC 19606 can grow without lipooligosaccharide (LOS). Lack of LOS can result from disruption of the early lipid A biosynthetic pathway genes lpxA, lpxC or lpxD. Although LOS itself is not essential for growth of A. baumannii ATCC
Daryl L Richie, Lisha Wang, Helen Chan, Gianfranco De Pascale, David A Six, Jun-Rong Wei, Charles R Dean   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Transcriptome and metabolome analysis reveals the effects of fatty acid degradation on flavonoid biosynthesis in apple

Fruit Research
In flavonoid biosynthesis, the phenylpropanoid branch has received increasing attention, but little attention has been paid to the fatty acid β-oxidation branch involved in providing the necessary malonyl-Coenzyme A (CoA) moieties of flavonoids. Here, we
Haoliang Wan, Tongtong Wang, Zhongyu Wang, Yuanming Zhou, Mengyao Yang, Kangni Yang, Jiyun Nie   +6 more
doaj   +1 more source

Transcriptome responses of Lactobacillus acetotolerans F28 to a short and long term ethanol stress

Scientific Reports, 2017
Lactobacillus acetotolerans is a major microbe contributing to the Chinese liquor fermentation with unknown function. It can be grown well in a high concentration of ethanol. RNA sequencing (RNA-seq) was performed on L.
Xiaopan Yang, Kunling Teng, Jie Zhang, Fangfang Wang, Tong Zhang, Guomin Ai, Peijie Han, Fengyan Bai, Jin Zhong   +8 more
doaj   +1 more source

Transcriptome-based analysis of the effects of salicylic acid and high light on lipid and astaxanthin accumulation in Haematococcus pluvialis

Biotechnology for Biofuels, 2021
Background The unicellular alga Haematococcus pluvialis has achieved considerable interests for its capacity to accumulate large amounts of triacylglycerol and astaxanthin under various environmental stresses.
Qunju Hu, Danqiong Huang, Anguo Li, Zhangli Hu, Zhengquan Gao, Yongli Yang, Chaogang Wang   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism [PDF]

Open Biology, 2017
Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex ...
Matías Cabruja, Sonia Mondino, Yi Ting Tsai, Julia Lara, Hugo Gramajo, Gabriela Gago   +5 more
doaj   +1 more source