Results 81 to 90 of about 404,405 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice

Molecular Metabolism, 2016
Objective: In this study, we analyzed the fatty acid profile of brains and plasma from male and female mice fed chow or a western-style high fat diet (WD) for 16 weeks to determine if males and females process fatty acids differently.
Carlos Rodriguez-Navas, Eugenia Morselli, Deborah J. Clegg   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The fatty acid composition of brain sphingolipids: sphingomyelin, ceramide, cerebroside, and cerebroside sulfate

Journal of Lipid Research, 1964
Sphingomyelin, ceramide, cerebroside, and cerebroside sulfate from beef brain were isolated by column chromatography in quantitative yield and in pure form. The fatty acid composition of each sphingolipid was determined by gas-liquid chromatography (GLC).
John S. O'Brien, George Rouser
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Lipid, fatty acid and protein utilization during lecithotrophic larval development of Lithodes santolla (Molina) and Paralomis granulosa (Jacquinot) [PDF]

, 2003
During the larval development of the subantarctic king crab, Lithodes santolla, and stone crab, Paralomis granulosa, we compared changes in the carbon, fatty acid and protein contents of larvae reared under constant conditions from hatching to ...
Kattner, G., Calcagno, J.A., Thatje, S., Graeve, Martin, Lovrich, G.A., Anger, K., Graeve, M., Calcagno, Javier Ángel, Anger, Klaus, Kattner, Gerhard, Lovrich, Gustavo Alejandro, Thatje, Sven, Calcagno, J. A., Lovrich, G. A.   +13 more
core   +1 more source

ALTERATION OF LIPID COMPOSITION OF BLUE MUSSELS MYTILUS EDULIS L. AS A RESULT OF THEIR ACCLIMATION TO LABORATORY CONDITIONS

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015
Organ-specific modifications and assimilation of trophic lipids, primarily of their fatty acids, were shown in the study of compensatory lipid and fatty acid composition changes in blue mussels Mytilus edulis L.
Natalia Fokina, Tatiana Ruokolainen, Nina Nemova, Igor Bakhmet   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

FATTY ACID COMPOSITION OF POULTRY MEAT FROM FREE RANGE REARING [PDF]

Poljoprivreda, 2000
Two provenances of broiler chickens (Ross and Prelux-bro) were (50 males and 50 females) were subjected to an extensive indoor rearing followed by a free-range rearing for a half of the population during the first 28 days.
Božidar Žlender, Antonija Holcman, Tomaž Polak, Vekoslava Stibil   +3 more
doaj