Results 101 to 110 of about 1,111,197 (376)

Targeting fatty acid metabolism in glioblastoma

The Journal of Clinical Investigation, 2023
Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and resistance to conventional therapies. There have been considerable efforts to untangle the metabolic underpinnings of this disease to find novel therapeutic avenues ...
Jason Miska, Navdeep S. Chandel
doaj   +1 more source

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

Journal of Experimental Medicine, 2016
Belkaid et al. show that type 2 innate lymphoid cells rely predominately on fatty acid metabolism during helminth infection and malnutrition.
C. Wilhelm, O. Harrison, V. Schmitt, M. Pelletier, S. Spencer, J. Urban, Michelle Ploch, T. Ramalingam, R. Siegel, Y. Belkaid   +9 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

From metagenomic data to personalized computational microbiotas: Predicting dietary supplements for Crohn's disease [PDF]

arXiv, 2017
Crohn's disease (CD) is associated with an ecological imbalance of the intestinal microbiota, consisting of hundreds of species. The underlying complexity as well as individual differences between patients contributes to the difficulty to define a standardized treatment.
arxiv  

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

Nature Communications, 2017
In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold
D. Blondin, H. Tingelstad, C. Noll, F. Frisch, S. Phoenix, B. Guérin, É. Turcotte, D. Richard, F. Haman, A. Carpentier   +9 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

Cell Reports, 2019
Summary: Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ T cells remain unclear. Here we show that deficiency in NIX-dependent
Shubhranshu S. Gupta, Robert Sharp, Colby Hofferek, Le Kuai, Gerald W. Dorn, II, Jin Wang, Min Chen   +6 more
doaj  

Metabolic Engineering of Oleaginous Yeast Yarrowia lipolytica for Overproduction of Fatty Acids

Frontiers in Microbiology, 2020
The oleaginous yeast Yarrowia lipolytica has attracted much attention due to its ability to utilize a wide range of substrates to accumulate high lipid content and its flexibility for genetic manipulation. In this study, intracellular lipid metabolism in
Rishikesh Ghogare, Shulin Chen, Xiaochao Xiong   +2 more
doaj   +1 more source

The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals [PDF]

Spiegelman B. Hormones, Metabolism and the Benefits of Exercise, Hormones, Metabolism and the Benefits of Exercise, Springer, pp.13-24, 2018, Research and Perspectives in Endocrine Interactions, 978-3-319-72789-9, 2019
To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed in essentially all eukaryotic cells as heterotrimeric complexes containing catalytic $\alpha$ subunits and ...
arxiv