Results 71 to 80 of about 1,111,197 (376)

Temperature dependence of mycosubtilin homologue production in Bacillus subtilis ATCC6633 [PDF]

, 2020
Bacillus subtilis ATCC6633 produces mycosubtilin, a non-ribosomally synthesized lipopeptide of the iturin family which presents antagonistic activities toward various phytopathogens. Different homologues with fatty acid moiety varying from C 15 to C 17 are usually co-produced, with their biological activities increasing with the number of carbons in ...
arxiv   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Shift workers are affected by circadian misalignment and have an increased risk to develop metabolic diseases such as type 2 diabetes.
Jakob Wefers, Dirk van Moorsel, Jan Hansen, N. J. Connell, B. Havekes, J. Hoeks, W. D. van Marken Lichtenbelt, H. Duez, E. Phielix, A. Kalsbeek, M. Boekschoten, G. Hooiveld, M. Hesselink, S. Kersten, B. Staels, F. Scheer, P. Schrauwen   +16 more
semanticscholar   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens

Frontiers in Nutrition, 2022
Non-alcoholic fatty liver disease (NAFLD) is a chronic and metabolic liver disease and commonly occurs in humans with obesity and type 2 diabetes mellitus (T2DM); such a condition also exists in animals such as rodents and laying hens.
Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Yan Li, Yan Li, Yan Li, Yan Li, Yan Li, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou   +44 more
doaj   +1 more source

When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance

Cancer Communications, 2018
The role of fatty acid metabolism, including both anabolic and catabolic reactions in cancer has gained increasing attention in recent years. Many studies have shown that aberrant expression of the genes involved in fatty acid synthesis or fatty acid ...
Ching-Ying Kuo, D. Ann
semanticscholar   +1 more source

Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells

Communications Biology, 2020
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of cancer, yet the relevance of HIF-1α to this process remains elusive. In this study,
Jieun Seo, D. Jeong, Jong-Wan Park, Kwang-Wonng Lee, J. Fukuda, Y. Chun   +5 more
semanticscholar   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Fatty Acid Metabolism-Related lncRNAs are Potential Biomarkers for Predicting Prognoses and Immune Responses in Patients with Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology, 2023
Xing Wang,1,2,* Xiaojing Yang,1,3,* Yiming Zhang,1 Afei Guo,1 Suju Luo,1 Meng Xiao,1 Lu Xue,1 Guohui Zhang,2 Huiping Wang1 1Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China ...
Wang X, Yang X, Zhang Y, Guo A, Luo S, Xiao M, Xue L, Zhang G, Wang H   +8 more
doaj  

Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue

Frontiers in Physiology, 2019
Increased physical activity is an optimal way to maintain a good health. During exercise, triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fatty acids (FAs) which are then released to the circulation, providing a fuel for ...
A. Mika, F. Macaluso, R. Barone, V. Di Felice, T. Śledziński   +4 more
semanticscholar   +1 more source