Results 261 to 270 of about 340,714 (313)

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

Unsaturated Fatty Acid Synthesis Is Associated with Worse Survival and Is Differentially Regulated by MYCN and Tumor Suppressor microRNAs in Neuroblastoma. [PDF]

Cancers (Basel)
Sheeter DA, Garza S, Park HG, Benhamou LE, Badi NR, Espinosa EC, Kothapalli KSD, Brenna JT, Powers JT.   +8 more
europepmc   +1 more source

Mitochondrial fatty acid synthesis is essential for coordinated energy transformation

, 2023
Haumann F, Evangelakos I, Worthmann A, Liebold I, Kotschi S, Bischoff AT, Neuhofer CM, Schweizer M, Heine M, the mitoNET consortium, Büchner B, Klopstock T, Prehn C, Dyar KA, Prokisch H, Bosurgi L, Heeren J, Bartelt A, Kubisch C, Schlein C.   +19 more
europepmc   +1 more source

Evidence for Regulation of Cholesterol and Fatty Acid Synthesis in Liver by Cyclic Adenosine 3′,5′-Monophosphate

, 1972
Lee A. Bricker, Gerald S. Levey
openalex   +1 more source

Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA

Advanced Science, EarlyView.
In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa, Rikako Sato, Mariko Konaka, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato   +5 more
wiley   +1 more source

Metabonomics and Transcriptomic Analysis of Free Fatty Acid Synthesis in Seedless and Tenera Oil Palm. [PDF]

Int J Mol Sci
Wei L, Yang C, John Martin JJ, Li R, Zhou L, Cheng S, Cao H, Liu X.   +7 more
europepmc   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

HIF2α Promotes Cancer Metastasis through TCF7L2-Dependent Fatty Acid Synthesis in ccRCC. [PDF]

Research (Wash D C)
Shi J, Lv Q, Miao D, Xiong Z, Wei Z, Wu S, Tan D, Wang K, Zhang X.   +8 more
europepmc   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Sirtuin 1 Inhibits Fatty Acid Synthesis through Forkhead Box Protein O1-Mediated Adipose Triglyceride Lipase Expression in Goat Mammary Epithelial Cells. [PDF]

Int J Mol Sci
He Q, Yao W, Lv L, Zhang X, Wu J, Luo J.
europepmc   +1 more source