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Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017Mitochondria and fatty acids are tightly connected to a multiplicity of cellular processes that go far beyond mitochondrial fatty acid metabolism. In line with this view, there is hardly any common metabolic disorder that is not associated with disturbed mitochondrial lipid handling. Among other aspects of mitochondrial lipid metabolism, apparently all
Alexander J. Kastaniotis +9 more
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The multifaceted roles of fatty acid synthesis in cancer
Nature Reviews Cancer, 2016Almut Schulze
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Fatty acid synthesis enables brain metastasis
Nature Cancer, 2021Cancer cells need to adapt their metabolic state to different microenvironments, particularly during metastatic spread, when they are exposed to the circulatory system as well as the distant organ. Two studies now show that upregulation of fatty acid synthesis is required for the formation of breast cancer metastasis in the lipid-poor environment of ...
Felix C. E. Vogel, Almut Schulze
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
Abstract 1. 1. The fatty-acid synthesizing capacity of guinea-pig heart is confined to the mitochondria; no synthesis of fatty acid could be demonstrated in the microsomal or soluble fractions. 2. 2. ATP citrate lyase (EC 4.1.3.8) and acetyl-CoA carboxylase (EC 6.4.1.2), which in rat liver were localized in the non-particulate fraction of the
E M, Wit-Peeters +2 more
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Abstract 1. 1. The fatty-acid synthesizing capacity of guinea-pig heart is confined to the mitochondria; no synthesis of fatty acid could be demonstrated in the microsomal or soluble fractions. 2. 2. ATP citrate lyase (EC 4.1.3.8) and acetyl-CoA carboxylase (EC 6.4.1.2), which in rat liver were localized in the non-particulate fraction of the
E M, Wit-Peeters +2 more
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REGULATION OF FATTY ACID SYNTHESIS
Annual Review of Plant Physiology and Plant Molecular Biology, 1997▪ Abstract All plant cells produce fatty acids from acetyl-CoA by a common pathway localized in plastids. Although the biochemistry of this pathway is now well understood, much less is known about how plants control the very different amounts and types of lipids produced in different tissues.
John B., Ohlrogge, Jan G., Jaworski
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Fatty acid synthesis enzyme clans
Biotechnology Letters, 2014Ketoacyl reductases (KRs), hydroxyacyl dehydratases (HDs), and enoyl reductases (ERs) are part of the fatty acid/polyketide synthesis cycle. They are known as acyl dehydrogenases, enoyl hydratases, and hydroxyacyl dehydrogenases, respectively, when catalyzing their reverse reactions. Earlier, we classified these enzymes into four KR, eight HD, and five
Ngoc N, Phan +2 more
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Mechanism of fatty acid synthesis
Life Sciences, 1977Abstract Significant advances have been made in the past few years in our understanding of the mechanism of synthesis of fatty acids, the structural organization of fatty acid synthetase complexes and the mechanism of regulation of activity of these enzyme systems.
S S, Katiyar, J W, Porter
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Fatty acid synthesis inTrichophyton rubrum
Mycopathologia et Mycologia Applicata, 1973Analysis of the fatty acid content ofT. rubrum showed that the organism is capable of synthesizing a variety of saturated and unsaturated long-chain fatty acids (Kostiw, Vicher &Lyon, 1966). The present study was undertaken to determine the mechanism of synthesis of these fatty acids.
L L, Kostiw, E E, Vicher, I, Lyon
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Carnitine esters of fatty acids support mitochondrial fatty acid synthesis
Biochemical and Biophysical Research Communications, 1970Abstract Acylcarnitines are active primers for mitochondrial fatty acid synthesis. It is suggested that another metabolic fate of carnitine esters of fatty acids in addition to their role in fatty acid oxidation is to provide substrates for mitochondrial fatty acid elongation.
J B, Warshaw, R E, Kimura
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