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Enzymatic synthesis of fatty acids

Comparative Biochemistry and Physiology, 1962
Abstract Available evidence indicates that there are two distinct systems for the synthesis of fatty acids. 1—The mitochondrial system which may involve some enzymes of the β-oxidation system plus TPNH-α-β-unsaturated acyl reductase and perhaps a new condensing enzyme. Both TPNH and DPNH are required for the synthesis.
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Synthesis of unsaturated fatty acids

Chemistry and Physics of Lipids, 1973
Abstract This article reviews synthetic routes leading to polyunsaturated fatty acids having “skipped” double bonds. Emphasis is placed on the “acetylenic approach”. The suitability of building blocks, their condensation reactions as well as the controlled reduction of triple bonds to cis double bonds are discussed. In addition, the application of
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Synthesis of Benzophenone-Containing Fatty Acids

The Journal of Organic Chemistry, 2006
Syntheses of new benzophenone-containing fatty acids (FABPs) 1, 5, and 6 and a new route to FABP 3 are described. Combined with the known 2 and 4, these FABPs comprise a set of photoactivatable fatty acid analogues with the crosslinking site at defined distances from the carboxylic acid hydroxyl group oxygen atoms ranging from 7.9 to 25.0 A.
Yonghong, Gan   +2 more
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FATTY ACID INHIBITION OF CHOLESTEROL SYNTHESIS

Canadian Journal of Biochemistry and Physiology, 1956
Fatty acids inhibit cholesterol synthesis by rat liver homogenates. Inhibition occurs with acids containing either an even or an odd number of carbon atoms in the chain, and with saturated and unsaturated acids, the inhibition increasing with the degree of unsaturation of the acid.
B B, MIGICOVSKY, J D, WOOD
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Fatty Acid Synthesis in Developing Brain

Neonatology, 1974
Acetyl-CoA carboxylase (EC 6.4.1.2) activity in the supernatant fraction of the rat brain is highest during the first 2 weeks of postnatal life, coincident with the period of maximal brain growth, and then declines by 50% to adult levels. As its <i>in vitro</i> activity is similar to that of fatty acid synthetase, it does not appear to be ...
I, Gross, J B, Warshaw
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Fatty acid synthesis in heart sarcosomes

Biochimica et Biophysica Acta, 1960
Abstract 1. 1. Heart sarcosomes catalyse the incorporation of acetate into a mixture of saturated and unsaturated long-chain fatty acids. 2. 2. ATP, coenzyme A, TPN + and certain Krebs-cycle intermediates are required for maximum activity. 3. 3. The hydrogen donors can be divided into two groups: (a) α-ketoglutarate, succinate and malate,
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Fatty acid synthesis in fetal lung

Biochemical and Biophysical Research Communications, 1980
Abstract De novo fatty acid synthesis in lung is significant during fetal growth and development. Specific activity and relative rate of synthesis of fatty acid synthetase increase with the days of gestational age and drop significantly after birth.
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Synthesis of Fatty Acids

1964
The enzyme synthesis of fatty acids has been studied for the most part in the fruit of the Fuerte or McArthur variety of the avocado (Stumpf and Barber, 1957 (1959); Mudd and Stumpf, 1961; Barron, Squires and Stumpf, 1961). The synthesis occurs in a particulate fraction of the cell that has all the properties of typical mitochondria i. e., sediments at
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Medium-chain fatty acid synthesis

Biochemical Society Transactions, 1986
J, Knudsen, H O, Hansen, J M, Mikkelsen
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