Results 61 to 70 of about 1,436,231 (357)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [PDF]

, 2015
Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.
Ala-Korpela, M, Casas, J-P, Chaturvedi, N, Fatemifar, G, Hingorani, AD, Hughes, AD, Jarvelin, M-R, Kahonen, M, Kangas, AJ, Kettunen, J, Kivimaki, M, Lawlor, DA, Lehtimaki, T, Mantyselka, P, Perola, M, Raitakari, OT, Salomaa, V, Sattar, N, Smith, GD, Soininen, P, Tiainen, M, Tillin, T, Tynkkynen, T, Vanhala, M, Wang, Q, Wurtz, P   +25 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

THE EFFECT OF HEMP PRЕSS CAKE FLOUR ON FATTY ACIDS COMPOSITION AND MICROBIOLOGICAL QUALITY OF GLUTEN FREE BREAD

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry
The aim of this paper is to determine the impact of hemp press cake flour (HPCF) on fatty acids and the microbiological quality of gluten-free bread. Seven types of gluten-free bread with different amounts of HPCF (0, 5, 10, 15, 20, 25 and 30 %) were ...
GJORE NAKOV , NATALIJA ATANASOVA-PANCEVSKA, SILVIYA IVANOVA , MARIA NIKOLOVA , IVAN DIMOV , MARKO JUKIĆ , JASMINA LUKINAC   +6 more
doaj   +1 more source

An in vitro model for essential fatty acid deficiency: HepG2 cells permanently maintained in lipid-free medium.

Journal of Lipid Research, 1992
A stable essential fatty acid-deficient cell type, known as HepG2-EFD, was derived from the lipoprotein-producing human hepatoma cell line HepG2. These cells are particularly useful for quantitative studies involving essential fatty acids (n-6 and n-3 ...
EE Furth, H Sprecher, EA Fisher, HD Fleishman, M Laposata   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Interactions Between Albumin and Fatty Acids Studied by NMR Spectroscopy

Chinese Journal of Magnetic Resonance, 2018
Fatty acids are important substrates for the synthesis of membrane phospholipids and other bioactive compounds, and thus play vital roles in mammalian energy metabolism. Fatty acids often bind to proteins in the blood.
GAO Dong-li, SUN Peng, WANG Qian-wen, LIU Mai-li, ZHANG Xu   +4 more
doaj   +1 more source

Evaluation of the Composition and Accumulation Pattern of Fatty Acids in Tartary Buckwheat Seed at the Germplasm Level

Agronomy, 2022
Tartary buckwheat seeds not only contain higher contents of bioactive flavonoids, but also are rich in fatty acids. However, the composition, accumulation patterns, and biosynthesis genes of fatty acids in Tartary buckwheat seeds remain largely unclear ...
Qiuyu Lv, Jiarui Wang, Peiyuan Sun, Fang Cai, Bin Ran, Jiao Deng, Taoxiong Shi, Qingfu Chen, Hongyou Li   +8 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Fatty Acid Composition of Novel Host Jack Pine Do Not Prevent Host Acceptance and Colonization by the Invasive Mountain Pine Beetle and Its Symbiotic Fungus. [PDF]

PLoS ONE, 2016
Fatty acids are major components of plant lipids and can affect growth and development of insect herbivores. Despite a large literature examining the roles of fatty acids in conifers, relatively few studies have tested the effects of fatty acids on ...
Guncha Ishangulyyeva, Ahmed Najar, Jonathan M Curtis, Nadir Erbilgin   +3 more
doaj   +1 more source

Fatty Acid Transport and Signaling: Mechanisms and Physiological Implications [PDF]

, 2022
Dmitri Samovski, Miriam Jácome-Sosa, Nada A. Abumrad   +2 more
openalex   +1 more source