Results 71 to 80 of about 1,254,981 (306)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias [PDF]

, 2017
Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates.
Aoki, Junken, Bolognini, Daniele, Hansen, Anders Højgaard, Hudson, Brian D., Inoue, Asuka, Kawakami, Kouki, Kishi, Takayuki, Milligan, Graeme, Sergeev, Eugenia, Ulven, Trond   +9 more
core   +3 more sources

Polyunsaturated Fatty Acids. IV.

Journal of Japan Oil Chemists' Society, 1960
Infrared absorption spectra of polyunsaturated fatty acid esters obtained from cuttle fish oils, showed a characteristic absorption at 1395cm-1, in addition to the typical absorption of normal fatty acid methylesters. This absorption at 1395cm-1 was related to the double bond, since by hydrogenation or autoxidation it was vanished away.Methyl linoleate,
Takaharu MIYAKAWA, Hideo NOMIZU
openaire   +4 more sources

Fatty Acid Compositions of Six Wild Edible Mushroom Species

The Scientific World Journal, 2013
The fatty acids of six wild edible mushroom species (Boletus reticulatus, Flammulina velutipes var. velutipes, Lactarius salmonicolor, Pleurotus ostreatus, Polyporus squamosus, and Russula anthracina) collected from different regions from Anatolia were ...
Pelin Günç Ergönül, Ilgaz Akata, Fatih Kalyoncu, Bülent Ergönül   +3 more
doaj   +1 more source

De novo synthesis and elongation of fatty acids by subcellular fractions of monkey aorta

Journal of Lipid Research, 1968
Subcellular fractions of aorta of squirrel monkey (Saimiri sciureus) were examined for their ability to synthesize and elongate fatty acids. High-speed supernate (HSS) incorporated substantial quantities of malonyl CoA into fatty acids while acetyl CoA ...
Charles F. Howard, Jr.
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
B. Koletzko, Bakker EC, Birch EE, Bouwstra H, C. Campoy, Chen IA, Decsi T, Decsi T, Decsi T, Dirix CE, Dirix CE, Donahue SM, Elias SL, Farquharson J, Franke C, G. Marchal, H. Demmelmair, Harvey KA, Helland IB, Jendryczko A, Koletzko B, Koletzko B, Krauss-Etschmann S, Kummerow FA, Lemaitre RN, L’Abbé MR, M. Cruz, M. Escolano, Mahfouz MM, Mahfouz MM, Makrides M, Morrison JA, Mozaffarian D, Parra MS, Roach C, S. Krauss-Etschmann, Sun Q, Szabó, Szabó, T. Decsi, T. Marosvölgyi, Thomas RM, van Eijsden M, van Houwelingen AC, É. Szabó   +44 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Quantitative determination of fatty acids in the University of Vermont\u27s CREAM herd followed over the course of six months [PDF]

, 2014
Holstein and Jersey cows were used to determine how the fatty acid profile of their milk differed with regard to breed of cow and season over the course of six months.
O\u27Day, John F, III
core   +1 more source

Studies on the compounds lipids from X-ray irradiated animal,1. [PDF]

, 1962
For the purpose to reveal the mechanism of the biological indirect action of X-rays the author has conducted the analysis of the compound lipids of the organs of the rabbits irradiated with X-rays.
Ohara, Sachiko
core   +1 more source