Results 71 to 80 of about 1,436,231 (357)

Unsaturated fatty acids [PDF]

, 2016
Fatty acids are long-chain hydrocarbons. They are called unsaturated fatty acids when they lack the maximum possible number of hydrogen atoms attached to every carbon atom. For example, if stearic acid, which has 18 carbon atoms and frequently occurs in animal and plant fats, is missing 2 hydrogen atoms, then a double bond is present and the resulting ...
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

De novo synthesis and elongation of fatty acids by subcellular fractions of monkey aorta

Journal of Lipid Research, 1968
Subcellular fractions of aorta of squirrel monkey (Saimiri sciureus) were examined for their ability to synthesize and elongate fatty acids. High-speed supernate (HSS) incorporated substantial quantities of malonyl CoA into fatty acids while acetyl CoA ...
Charles F. Howard, Jr.
doaj   +1 more source

Polyunsaturated Fatty Acids. IV.

Journal of Japan Oil Chemists' Society, 1960
Infrared absorption spectra of polyunsaturated fatty acid esters obtained from cuttle fish oils, showed a characteristic absorption at 1395cm-1, in addition to the typical absorption of normal fatty acid methylesters. This absorption at 1395cm-1 was related to the double bond, since by hydrogenation or autoxidation it was vanished away.Methyl linoleate,
Takaharu MIYAKAWA, Hideo NOMIZU
openaire   +4 more sources

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
B. Koletzko, Bakker EC, Birch EE, Bouwstra H, C. Campoy, Chen IA, Decsi T, Decsi T, Decsi T, Dirix CE, Dirix CE, Donahue SM, Elias SL, Farquharson J, Franke C, G. Marchal, H. Demmelmair, Harvey KA, Helland IB, Jendryczko A, Koletzko B, Koletzko B, Krauss-Etschmann S, Kummerow FA, Lemaitre RN, L’Abbé MR, M. Cruz, M. Escolano, Mahfouz MM, Mahfouz MM, Makrides M, Morrison JA, Mozaffarian D, Parra MS, Roach C, S. Krauss-Etschmann, Sun Q, Szabó, Szabó, T. Decsi, T. Marosvölgyi, Thomas RM, van Eijsden M, van Houwelingen AC, É. Szabó   +44 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Geochemical Characteristics of the Fatty Acids in the Core Sediments in the Northern South Yellow Sea

Journal of Marine Science and Engineering
The geochemistry of the fatty acids in the modern sediments in the Northern South Yellow Sea is still poorly studied, and studies on the geochemistry of the fatty acids in relatively long-core sediment samples are lacking.
Jinxian He, Xiaoli Zhang, Ruihua Ma, Zhengxin Huang, Juhao Li, Peilin Sun, Jiayao Song   +6 more
doaj   +1 more source

Lipopolysaccharide-specific acyloxyacyl hydrolase [PDF]

, 1991
" An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids from their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being being bound in turn to lipopolysaccharide ...
Hall, Catherine L., Munford, Robert S.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Organic chemical signatures of New Zealand carbonate concretions and calcite fracture fills as potential fluid migration indicators [PDF]

, 2006
Macroscopic calcite crystals are common in sedimenta¬ry strata, occurring both as tectonic veins and also filling one or more generations of septarian rupture or later brittle fractures in calcareous concretions.
Nelson, Campbell S., Pearson, Michael J.
core   +1 more source