Results 81 to 90 of about 1,254,981 (306)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Generation of cloned transgenic pigs rich in omega-3 fatty acids [PDF]

, 2006
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase.
August Rieke, Clifton N Murphy, David M Wax, Hwan Yul Yong, Jing X Kang, Jingdong Wang, JP Spychalla, JX Kang, L Lai, Liangxue Lai, Melissa Samuel, Michael L Linville, PRC Howe, Randall S Prather, Rhobert W Evans, Rongfeng Li, Scott W Korte, Thomas E Starzl, William T Witt, Y Dai, Yanhong Hao, Yifan Dai   +21 more
core   +1 more source

The Geochemical Characteristics of the Fatty Acids in the Core Sediments in the Northern South Yellow Sea

Journal of Marine Science and Engineering
The geochemistry of the fatty acids in the modern sediments in the Northern South Yellow Sea is still poorly studied, and studies on the geochemistry of the fatty acids in relatively long-core sediment samples are lacking.
Jinxian He, Xiaoli Zhang, Ruihua Ma, Zhengxin Huang, Juhao Li, Peilin Sun, Jiayao Song   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Organic chemical signatures of New Zealand carbonate concretions and calcite fracture fills as potential fluid migration indicators [PDF]

, 2006
Macroscopic calcite crystals are common in sedimenta¬ry strata, occurring both as tectonic veins and also filling one or more generations of septarian rupture or later brittle fractures in calcareous concretions.
Nelson, Campbell S., Pearson, Michael J.
core   +1 more source

Fatty Acids

, 2021
Milk fat is one of the most complex lipid matrices, with more than 400 different fatty acids (FA) in its composition and most of them at trace levels. In the past decades, important achievements have been achieved in regard to dairy fat FA analysis due to the remarkable development of modern analytical techniques.
Gómez-Cortés, Pilar, Juárez, Manuela, Fuente, Miguel Ángel de la   +2 more
openaire   +2 more sources

Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation

Animal, 2008
Heating oils and fats may lead to cyclization of polyunsaturated fatty acids, especially those showing multiple double bonds like linolenic acid. Cyclohexenyl and cyclopentenyl fatty acids are subsequently present in some edible oils and these were ...
L. Bretillon, A. Roy, B. Pasquis, J.-L. Sébédio   +3 more
doaj   +1 more source

Milk urea nitrogen and milk fatty acid compositions in dairy cows with subacute ruminal acidosis

Veterinární Medicína, 2020
The present study was aimed at comparing the milk urea nitrogen (MUN) and milk fatty acid (MFA) compositions in Holstein cows with subacute ruminal acidosis (SARA) to those values of Holstein cows that did not have SARA.
Kanber Kara
doaj   +1 more source

Fatty acid composition of ostrich (Struthio camelus) abdominal adipose tissue [PDF]

Macedonian Veterinary Review, 2015
Fatty acid composition of foods has a great impact on nutrition and health. Therefore, thе determination and knowledge of the fatty acid composition of food is very important for nutrition.
Daniela Belichovska, Zehra Hajrulai-Musliu, Risto Uzunov, Katerina Belichovska, Mila Arapcheska   +4 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source