Results 81 to 90 of about 705,039 (343)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Pathomechanism of Insulin Resistance in Men with Central Obesity: Correlation of GGT, GPx, Hs-CRP and Plasma Total Cysteine [PDF]

, 2013
BACKGROUND: Gamma glutamyltransferase (GGT) was reported recently to be associated with inflammation, oxidative stress and increased amino acid. However, role of GGT in insulin resistance pathomechanism is not exactly known.
Patellongi, I. (Ilhamjaya), Ritawaty, R. (Ritawaty), Sandra, F. (Ferry), Sukmawati, I. R. (Indriyanti)   +3 more
core   +4 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Immunoglobulin A and liver diseases. [PDF]

, 2017
Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium ...
Inamine, Tatsuo, Schnabl, Bernd
core   +2 more sources

Association between eGDR and MASLD and liver fibrosis: a cross-sectional study based on NHANES 2017–2023

Frontiers in Medicine
BackgroundThis study aimed to investigate the association between estimated glucose disposal rate (eGDR) and metabolic dysfunction-associated steatotic liver disease (MASLD), as well as liver fibrosis, using data from the National Health and Nutrition ...
Wenjing Peng, Zeyu Li, Nian Fu
doaj   +1 more source

Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced GeneSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and Aims: Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic fatty liver disease (NAFLD).
Ze-Hua Zhao, Zi-Xuan Wang, Da Zhou, Yamei Han, Fengguang Ma, Zhimin Hu, Feng-Zhi Xin, Xiao-Lin Liu, Tian-Yi Ren, Feifei Zhang, Yaqian Xue, Aoyuan Cui, Zhengshuai Liu, Jinyun Bai, Yuxiao Liu, Genxiang Cai, Weitong Su, Xiaozhen Dai, Feng Shen, Qin Pan, Yu Li, Jian-Gao Fan   +21 more
doaj  

Fatty liver with metabolic disorder, such as metabolic dysfunction‐associated fatty liver disease, indicates high risk for developing diabetes mellitus

Journal of Diabetes Investigation, 2022
Introduction Nonalcoholic fatty liver disease (NAFLD) is diagnosed after excluding other liver diseases. The pathogenesis of NAFLD when complicated by other liver diseases has not been established completely.
Teruki Miyake, Bunzo Matsuura, Shinya Furukawa, Toru Ishihara, Osamu Yoshida, Masumi Miyazaki, Kyoko Watanebe, Akihito Shiomi, Hironobu Nakaguchi, Yasunori Yamamoto, Yohei Koizumi, Yoshio Tokumoto, Masashi Hirooka, Eiji Takeshita, Teru Kumagi, Masanori Abe, Yoshio Ikeda, Takeru Iwata, Yoichi Hiasa   +18 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia, Coste, Sorina Cezara, Cozma, Angela, Negrean, Vasile, Orasan, Olga Hilda, Popovici, Ionela, Procopciuc, Lucia Maria, Sampelean, Dorel, Sitar Taut, Adela, Stefan, Andreea Maria, Tarmure Sarlea, Simina   +10 more
core   +1 more source