Results 51 to 60 of about 15,385 (260)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fault location of distribution networks based on multi-source information

Global Energy Interconnection, 2020
In order to promote the development of the Internet of Things (loT), there has been an increase in the coverage of the customer electric information acquisition system (CEIAS).
Wenbo Li, Jianjun Su, Xin Wang, Jiamei Li, Qian Ai   +4 more
doaj   +1 more source

On the Complexity of Fault-Tolerant Consensus [PDF]

, 2019
The paper studies the problem of reaching agreement in a distributed message-passing system prone to crash failures. Crashes are generated by \constrained\ adversaries - a \wadapt\ adversary, who has to fix in advance the set of $f$ crash-prone processes, or a \chainadapt\ adversary, who orders all the processes into $k$ disjoint chains and has to ...
Dariusz R. Kowalski, Jaroslaw Mirek
openaire   +2 more sources

Fault-tolerant geometric spanners [PDF]

Proceedings of the nineteenth annual symposium on Computational geometry, 2003
We present two new results about vertex and edge fault-tolerant spanners in Euclidean spaces. We describe the first construction of vertex and edge fault-tolerant spanners having optimal bounds for maximum degree and total cost. We present a greedy algorithm that for any \(t > 1\) and any non-negative integer \(k\), constructs a \(k\)-fault-tolerant ...
Artur Czumaj, Hairong Zhao
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design of the fault tolerant command and data handling subsystem for ESTCube-1; pp. 222–231 [PDF]

Proceedings of the Estonian Academy of Sciences, 2014
This paper presents the design, implementation, and pre-launch test results of the Command and Data Handling Subsystem (CDHS) for ESTCube-1. ESTCube-1 is a one-unit CubeSat, which will perform an electric solar wind sail experiment.
Kaspars Laizans, Indrek Sünter, Karlis Zalite, Henri Kuuste, Martin Valgur, Karl Tarbe, Viljo Allik, Georgi Olentšenko, Priit Laes, Silver Lätt, Mart Noorma   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Networking Microcontrollers and Balancing the Load on the Service Servers to Enhance the Fault Tolerance of the IoT Networks

Mathematics
Different types of faults occur in different layers of IoT networks, which affect their fault tolerance. The Controller and Services layers are the weakest links in an IoT network, and any failure in these layers drastically reduces its fault tolerance ...
Sastry Kodanda Rama Jammalamadaka, Bhupati Chokra, Sasi Bhanu Jammalamadaka, Balakrishna Kamesh Duvvuri   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source