Results 61 to 70 of about 15,385 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Unifying flavors of fault tolerance with the ZX calculus [PDF]

Quantum
There are several models of quantum computation which exhibit shared fundamental fault-tolerance properties. This article makes commonalities explicit by presenting these different models in a unifying framework based on the ZX calculus.
Hector Bombin, Daniel Litinski, Naomi Nickerson, Fernando Pastawski, Sam Roberts   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An Efficient Fault-Tolerant Scheduling Approach with Energy Minimization for Hard Real-Time Embedded Systems

Cybernetics and Information Technologies, 2019
In this paper, we focus on two major problems in hard real-time embedded systems fault tolerance and energy minimization. Fault tolerance is achieved via both checkpointing technique and active replication strategy to tolerate multiple transient faults ...
Kada Barkahoum, Kalla Hamoudi
doaj   +1 more source

Active fault-tolerance of the unmanned aerial vehicle automatic control systems

International Journal of Aviation, Aeronautics, and Aerospace, 2020
This paper presents an introductory overview of principles of the three-layer hierarchy of active fault-tolerance, providing, determination of the fault type with as many details as enough to get recoverable fault reason and failure toleration by ...
Vuong Anh Trung, Nguyen Van Thinh, Nguyen Duc Thanh, Nguyen Quang Vinh, Tran Thuan Hoang   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Dependability in Embedded Systems: A Survey of Fault Tolerance Methods and Software-Based Mitigation Techniques

IEEE Access
Fault tolerance is a critical aspect of modern computing systems, ensuring correct functionality in the presence of faults. This paper presents a comprehensive survey of fault tolerance methods and mitigation techniques in embedded systems, with a focus ...
Mohammadreza Amel Solouki, Shaahin Angizi, Massimo Violante   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The optimization of global fault tolerant trajectory for redundant manipulator based on self-motion

MATEC Web of Conferences, 2015
The redundancy feature of manipulators provides the possibility for the fault tolerant trajectory planning. Aiming at the completion of the specific task, an algorithm of global fault tolerant trajectory optimization for redundant manipulator based on ...
Zhang Jian, Jia Qingxuan, Chen Gang, Sun Hanxu, Li Tong   +4 more
doaj   +1 more source