Results 61 to 70 of about 2,461,573 (347)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Event-B Patterns for Specifying Fault-Tolerance in Multi-Agent Interaction

open access: yes, 2007
Interaction in a multi-agent system is susceptible to failure. A rigorous development of a multi-agent system must include the specification of fault-tolerance in agent interactions for the agents to be able to continue to function independently ...
Ball, Elisabeth   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Data criticality estimation in software applications [PDF]

open access: yes, 2003
In safety-critical applications it is often possible to exploit software techniques to increase system's fault- tolerance. Common approaches are based on data redundancy to prevent data corruption during the software execution.
Di Natale, Giorgio   +9 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Investigation into fault tolerant capability of new modular low‐speed and high‐torque direct‐drive permanent magnet motor based on unequal span winding

open access: yesIET Electric Power Applications, 2021
Low‐speed and high‐torque direct‐drive permanent‐magnet motors have found wide applications primarily due to their outstanding performance characteristics.
Baoping Gan   +3 more
doaj   +1 more source

Fault-tolerant broadcasts

open access: yesScience of Computer Programming, 1984
In computer networks, fault-tolerant broadcast ensures delivery of messages to the functioning network nodes despite the fact that nodes may fail at any time. In this paper, a fault-tolerant broadcast protocol that works with any broadcast strategy is pesented and proved correct.
Fred B. Schneider   +2 more
openaire   +2 more sources

Fault tolerant network constructors [PDF]

open access: yesInformation and Computation, 2019
In this work, we consider adversarial crash faults of nodes in the network constructors model $[$Michail and Spirakis, 2016$]$. We first show that, without further assumptions, the class of graph languages that can be (stably) constructed under crash faults is non-empty but small.
Othon Michail   +2 more
openaire   +5 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Research on co-design of dual security control and communication for nonlinear CPS with actuator fault and FDI attacks

open access: yesMeasurement + Control, 2022
In this study, a co-design method of dual security control and communication is investigated for a nonlinear cyber–physical system (CPS) with an actuator fault and false data injection (FDI) attacks.
Li Zhao, Wei Li, YaJie Li
doaj   +1 more source

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