Results 101 to 110 of about 1,461,059 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Two‐Step Clustering‐Based Equivalent Modeling of Large‐Scale Wind Farms for Enhanced Primary Frequency Regulation

Wind Energy
The focus on wind power frequency regulation has largely been on individual wind farms, which presents challenges in meeting the coordinated operation needs of multiple stations within large‐scale installations.
Hongchun Shu, Liuqing Zhu, Botao Shi, Guangxue Wang, Shunguang Lei   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adaptability analysis of distance protection in flexible low frequency ac outgoing transmission line of wind power system

Results in Engineering
The extension of offshore wind power to medium and far seas has promoted the development of flexible low-frequency AC transmission (FLFAC) technology. However, the fault responses of the power electronic interface-type power sources (wind turbines and ...
Yue Dai, Hongchun Shu, Yutao Tang, Haoming Liu   +3 more
doaj   +1 more source

Anomaly Detection and Removal Using Non-Stationary Gaussian Processes

, 2015
This paper proposes a novel Gaussian process approach to fault removal in time-series data. Fault removal does not delete the faulty signal data but, instead, massages the fault from the data.
Garnett, Roman, Osborne, Michael, Reece, Steven, Roberts, Stephen   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pilot protection based on the quasi-directional element of LCL-tuned half-wavelength transmission line

International Journal of Electrical Power & Energy Systems
To create HWTL characteristics, the electrical distance of AC transmission lines is compensated to half the power frequency wavelength by utilizing tuned circuits.
Yutao Tang, Hongchun Shu, Yue Dai, Yu Zhang, Yiming Han   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Time-domain impedance pilot protection of MMCHVDC transmission line based on modulus characteristics

Results in Engineering
Flexible HVDC transmission systems provide flexible and efficient solutions for new energy grid integration and asynchronous interconnection of AC systems, and represent a major trend in the future development of power grids.
Yue Dai, Hongchun Shu, Haoming Liu, Xuefei Zhang, Yutao Tang, Na An   +5 more
doaj   +1 more source

Laboratory Research on Fracture-Supported Shielding Temporary Plugging Drill-In Fluid for Fractured and Fracture-Pore Type Reservoirs

Journal of Chemistry, 2017
Based on fractures stress sensitivity, this paper experimentally studies fracture-supported shielding temporary plugging drill-in fluid (FSDIF) in order to protect fractured and fracture-pore type formation. Experimental results show the FSDIF was better
Dawei Liu, Yili Kang, Quanwen Liu, Dengsheng Lei, Bo Zhang   +4 more
doaj   +1 more source