Results 121 to 130 of about 435,309 (318)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The Incentive Effects of No Fault Automobile Insurance [PDF]

open access: yes
This paper presents a theoretical and empirical analysis of the effects of no fault automobile insurance on accident rates. As a mechanism for compensating the victims of automobile accidents, no fault has several important advantages over the tort ...
J. David Cummins   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Dynamic Voltage Scaling Aware Delay Fault Testing

open access: yes, 2006
The application of Dynamic Voltage Scaling (DVS) to reduce energy consumption may have a detrimental impact on the quality of manufacturing tests employed to detect permanent faults.
Zain Ali, Noohul Basheer   +3 more
core  

On parametric solution of fault detection problems

open access: yes, 2011
We discuss the solution of the fault detection problem in presence of parametric uncertainties. The basic approach is an extension of the nullspace method for constant systems to the case of linear parameter varying (LPV) models.
Andras Varga, Varga, A.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Backup protection method for half-wavelength transmission lines based on inverse-time characteristic

open access: yesInternational Journal of Electrical Power & Energy Systems
The advantages of ultra-high voltage (UHV) Half-wavelength AC transmission (HWACT) technology are achieving full-line reactive power self-balancing without the need for reactive power compensation equipment along the line and avoiding the Ferranti effect.
Hongchun Shu   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Superconducting fault current limiter application in a power-dense marine electrical system

open access: yes, 2011
Power-dense, low-voltage marine electrical systems have the potential for extremely high fault currents. Superconducting fault current limiters (SFCLs) have been of interest for many years and offer an effective method for reducing fault currents.
Burt, Graeme   +11 more
core   +1 more source

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