Results 111 to 120 of about 435,309 (318)

Laboratory Research on Fracture-Supported Shielding Temporary Plugging Drill-In Fluid for Fractured and Fracture-Pore Type Reservoirs

Journal of Chemistry, 2017
Based on fractures stress sensitivity, this paper experimentally studies fracture-supported shielding temporary plugging drill-in fluid (FSDIF) in order to protect fractured and fracture-pore type formation. Experimental results show the FSDIF was better
Dawei Liu, Yili Kang, Quanwen Liu, Dengsheng Lei, Bo Zhang   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SystemC-based Minimum Intrusive Fault Injection Technique with Improved Fault Representation

In this paper, we propose a new SystemC-based fault injection technique that has improved fault representation in visible and on-the-fly data and signal registers.
Rosinger, Paul, Al-Hashimi, Bashir, Shafik, Rishad   +2 more
core  

Time-domain impedance pilot protection of MMCHVDC transmission line based on modulus characteristics

Results in Engineering
Flexible HVDC transmission systems provide flexible and efficient solutions for new energy grid integration and asynchronous interconnection of AC systems, and represent a major trend in the future development of power grids.
Yue Dai, Hongchun Shu, Haoming Liu, Xuefei Zhang, Yutao Tang, Na An   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development and interaction of segmented fault systems

, 1998
Faults in contractional and extensional settings have been studied, both during fieldwork and from interpretation of 2D and 3D seismic sections. Detailed analysis of the geometries of faults, with displacements of a few mm to 100's m, has provided ...
Kelly, P.G.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Enhanced pilot protection scheme for half-wavelength transmission line based on the conservation of traveling wave energy

International Journal of Electrical Power & Energy Systems
The half-wavelength transmission system is a viable technology for long-distance and large-capacity power transmission. It can safely and efficiently transmit a large amount of clean energy to remote load centers.
Yutao Tang, Hongchun Shu, Yue Dai, Yiming Han   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Novel Sub-Module-Based Line-Commutated Converter That Is Actively Resistant to Commutation Failure

Actuators
To improve the ability of line-commutated converters (LCCs) to resist commutation failure (CF) when a fault occurs on the AC side, a novel sub-module-based LCC topology actively resistant to CF is proposed in this paper.
Hongchun Shu, Junjie Zhang, Yaoxi Jiang
doaj   +1 more source