Results 101 to 110 of about 539,809 (286)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Preliminary study on the Late Quaternary activity of important active fault zones along the Yunnan-Tibet railway

地震科学进展
The Yunnan-Tibet railway is located in the southeastern edge of the Tibetan Plateau, where tectonic plates collide and the terrain rapidly changes. Along the line, active faults develops, earthquakes occur frequently, and the intensity of earthquakes is ...
Xianbing Zhang, Hao Yu, Xiao Yu, Changbao Guo, Rui’an Wu, Yang Wang, Ning Zhong   +6 more
doaj   +1 more source

Expresión geomorfológica de la actividad reciente de la falla de Amer (NE de la Península Ibérica) [PDF]

, 1996
Triangular facets, related drainage basins, alluvial fans and subtle scarps reveal the recent activity of the normal Amer fault (NE Spain). The 1427 earthquakes which reached epicentral intensities ranging between VI1 and VI11 have been attributed to the
Ferrer, P., Masana, E., Santanach, Pere
core   +1 more source

Persistence and Quiescence of Seismicity on Fault Systems

, 1999
We study the statistics of simulated earthquakes in a quasistatic model of two parallel heterogeneous faults within a slowly driven elastic tectonic plate.
A. J. Crone, B. Derrida, D. Sornette, D. Sornette, D. Sornette, Didier Sornette, H.-J. Xu, J. P. Bouchaud, L. Knopoff, Leon Knopoff, Matthew W. Lee, P. Cowie, P. Miltenberger, S. Beanland, S. N. Majumdar, S. N. Majumdar, S. N. Majumdar, W. Horsthemke   +17 more
core   +1 more source

Supporting group maintenance through prognostics-enhanced dynamic dependability prediction [PDF]

, 2017
Condition-based maintenance strategies adapt maintenance planning through the integration of online condition monitoring of assets. The accuracy and cost-effectiveness of these strategies can be improved by integrating prognostics predictions and ...
Aizpurua, J. I., Aizpurua, Jose Ignacio, Catterson, V. M., Catterson, Victoria, Chiacchio, F., Chiacchio, Ferdinando, D'Urso, D., D'Urso, Diego, Papadopoulos, Y., Papadopoulos, Yiannis   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Does the Fault System Optimally Control Primary Accident Costs? [PDF]

, 1968
For the purposes of this article, I shall assume that the sole aim of any system of accident law is the minimization of the sum of (a) accident costs and (b) the cost of avoiding accident costs.
Calabresi, Guido
core   +2 more sources

Interseismic strain accumulation: Spin-up, cycle invariance, and irregular rupture sequences [PDF]

, 2006
Using models of infinite length strike-slip faults in an elastic layer above linear viscoelastic regions, we investigate interseismic deformation. In the models we investigate, interseismic strain accumulation on mature faults is the result of the ...
Hager, B. H., Hetland, E. A.
core   +1 more source