Results 111 to 120 of about 539,809 (286)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Co-Seismic and Post-Seismic Slip Properties Associated with the 2024 M 7.5 Noto Peninsula, Japan Earthquake Determined by GNSS Observations

Remote Sensing
Based on GNSS observations, the co-seismic and post-seismic slip of the 2024 Noto Peninsula earthquake and the spatio-temporal pattern of afterslip are investigated in this paper. The co-seismic slip is mainly distributed in the depth range of 2 to 15 km
Yunfei Xiang, Ming Qin, Yuanyuan Chen, Yin Xing, Yankai Bian   +4 more
doaj   +1 more source

Corinth Rift Active Crustal Fault Flexure

, 2018
Oral Presentation EGU 2018EGU2018-12411 TS6.1/GD6.2/GM4.7/GMPV8.6/SSP3.17Corinth Rift active crustal fault flexureDavid Fernández-Blanco, Gino de Gelder, Sean Gallen, Guillaume Duclaux, Rebecca Bell, Robin Lacassin and Rolando Armijo Presented on Apr 10th 2018 in ...
Fernández-Blanco, David, de Gelder, Gino, Gallen, Sean, Duclaux, Guillaume, Bell, Rebecca, Lacassin, Robin, Armijo, Rolando   +6 more
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

History and morphology of faulting in the Noctis Labyrinthus-Claritas Fossae Region of Mars [PDF]

The topographically high areas cut by Noctis Labyrinthus, Noctis Fossae, and Claritas Fossae were subjected to only minor resurfacing during and following local tectonic activity.
Davis, Philip A., Tanaka, Kenneth L.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Characteristics, causes and significance of subsurface stress field of Beijing earth fissures group

Geomatics, Natural Hazards & Risk
The development of earth fissures in a certain area often has certain genetic correlations, which is called ‘group-developing phenomenon’ of earth fissures. So far, 41 earth fissures have developed in the Beijing area in the North China Plain.
Jishan Xu, Jianbing Peng, Yahong Deng, Haibo An, Zhenjiang Meng, Yan Wang, Zuodong Li   +6 more
doaj   +1 more source

Segmentation of Fault Networks Determined from Spatial Clustering of Earthquakes

, 2010
We present a new method of data clustering applied to earthquake catalogs, with the goal of reconstructing the seismically active part of fault networks.
Allégre, Ben-Zion, Ben-Zion, Bishop, Bowman, Corduneanu, D. Sornette, de Joussineau, Duda, Eneva, Faulkner, G. Ouillon, Gardner, Hauksson, Hauksson, Helmstetter, Helmstetter, Helmstetter, Helmstetter, Kagan, Kagan, Kagan, Kagan, Kagan, Kagan, Kilb, Knopoff, Liu, Lyakhovsky, MacQueen, Manighetti, Marsan, Martel, Martel, Miltenberger, Nemser, Ouillon, Ouillon, Ouillon, Ouillon, Pisarenko, Plesch, Powers, Reasenberg, Robertson, Scholz, Scholz, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Vermilye, Waldhauser, Wang, Weatherley, Willemse, Wilson, Zhou, Zhuang, Zhuang   +63 more
core   +1 more source