Results 121 to 130 of about 539,809 (286)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Regional fluvial geomorphic index and terrace downcutting process in the southern section of Lishi fault in Shanxi Province and their tectonic significance

地震科学进展
Based on digital elevation model (DEM), field river terrace survey and optical stimulated luminescence dating (OSL) dating, the slope, relief degree of land surface (RDLS), hypsometric integral (HI) and channel steepness index (Ksn) of the southern ...
Xing’ao Li, Zhongtai He, Xuanyue Lei, Linlin Li, Junxiang Zhao   +4 more
doaj   +1 more source

Improving the Knowledge on Seismogenic Sources in the Lower Tagus Valley for Seismic Hazard Purposes [PDF]

, 2012
The Lower Tagus Valley, that includes the metropolitan area of Lisbon, has been struck by several earthquakes which produced significant material damage and loss of lives. Their exact location remains unknown.
Borges, J. F., Caldeira, B., Carvalho, J., Costa, M., Dias, R., Duarte, H., Pinto, C. C., Rabeh, T, Terrinha, P.   +8 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Characteristics and Tectonic Implications of the Geomorphic Indices of the Watersheds Around the Lijiang–Jinpingshan Fault

Remote Sensing
The Lijiang–Jinpingshan fault (LJF) is an important secondary boundary fault that obliquely cuts the Sichuan–Yunnan rhombic block. It is of great significance for understanding the tectonic evolution of the Sichuan–Yunnan rhombic block and even the ...
Yongqi Chen, Rui Ding, Shimin Zhang, Dawei Jiang, Luyao Li, Diwei Hua   +5 more
doaj   +1 more source

Post-carboniferous tectonics in the Anadarko Basin, Oklahoma: Evidence from side-looking radar imagery [PDF]

The Anadarko Basin of western Oklahoma is a WNW-ESE elongated trough filled with of Paleozoic sediments. Most models call for tectonic activity to end in Pennsylvanian times.
Nielsen, K. C., Stern, R. J.
core   +1 more source

Estimation of Activity of the Active Fault.

Journal of Geography (Chigaku Zasshi), 1992
The nature of active faults is reviewed to estimate future activity. Criteria for the prediction of large earthquakes are given based on active faults and some earthquake-expectancy maps are shown.The activity of active faults is of a cyclic nature.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Tectonic Geomorphology and Quaternary Activity Characteristics of the Jining River Northern Margin Fault, Inner Mongolia, North China

Applied Sciences
The Jining River northern margin fault is a newly discovered Quaternary active fault, located at the junction of the northeastern corner of the Ordos Block and the Yinshan-Yanshan Uplift (Jining District, Ulanqab, Inner Mongolia). The northeastern margin
Haowen Ma, Shaopeng Dong
doaj   +1 more source