Results 81 to 90 of about 539,809 (286)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Activity of the Mianzishan-Qingshuiying fault in the southeast margin of the Yinchuan basin
地震科学进展Studying the tectonic activity characteristics of the Yinchuan basin is of great significance for understanding the interaction among the three major blocks of Qinghai Tibet, Ordos and Alxa.
Zhiqun Wu +5 more
doaj +1 more source
BSGF - Earth Sciences Bulletin, 2017 Analysis of offshore seismic lines suggests that a strong relationship exists between tectonic structures and fluid migration in accretionary prisms.
Malie Pierre +8 more
doaj +1 more source
The origin of fault scarps & fissures on moorland plateaux & in the vicinity of landslides, in the South Wales Coalfield, UK [PDF]
, 2010 Fault scarps and fissures occur on moorland plateaux and in the vicinity of deep-seated landslides in the South Wales Coalfield, UK. These scarps may reach about 4 m in height and 3-4 km in length.
Donnelly, L.J. +2 more
core
The Strict Liability in Fault and the Fault in Strict Liability [PDF]
, 2016 Tort scholars have long been obsessed with the dichotomy between strict liability and liability based on fault or wrongdoing. We argue that this is a false dichotomy.
Goldberg, John C.P. +1 more
core +2 more sources
A Setup for Active Fault Diagnosis [PDF]
IEEE Transactions on Automatic Control, 2006 A setup for active fault diagnosis (AFD) of parametric faults in dynamic systems is formulated in this note. It is shown that it is possible to use the same setup for both open loop systems, closed-loop systems based on a nominal feedback controller as well as for closed-loop systems based on a reconfigured feedback controller.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Shiyou shiyan dizhiTo enhance the development efficiency of ultra-deep fault-controlled carbonate reservoirs, large-scale rock mechanical experiments were conducted to reveal the deformation and connectivity mechanisms of high-angle to near-vertical fault surfaces.
Zhenzhong CAI +7 more
doaj +1 more source
Identification and interpretation of tectonic features from Skylab imagery [PDF]
The author has identified the following significant results. S190-B imagery confirmed previous conclusions from S190-A that the Garlock fault does not extend eastward beyond its known termination near the southern end of Death Valley.
Abdel-Gawad, M.
core +2 more sources